Document Detail

Acute hydralazine overdose: marked ECG abnormalities in a young adult.
MedLine Citation:
PMID:  1536497     Owner:  NLM     Status:  MEDLINE    
Although hydralazine is a commonly prescribed antihypertensive agent, reports of acute human poisoning are uncommon. Most of the literature focuses on chronic toxicity, most notably, the drug-induced systemic lupus erythematosus syndrome. A case of acute hydralazine overdose associated with marked ECG ST segment depression in a young adult is presented. Although the patient also had mild hypotension, acidemia, and ethanol intoxication, the ECG abnormality was alarming and suggestive of myocardial ischemia. The patient was managed conservatively in an ICU setting, and the metabolic and ECG abnormalities resolved. No reports of such marked ECG changes associated with acute hydralazine poisoning in a young adult could be found. Clinical and experimental data on acute hydralazine exposure suggest that the possibility of direct drug effects, including positive inotropic and chronotropic effects and myocardial cell injury, should be considered.
B A Smith; D B Ferguson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  21     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-03-26     Completed Date:  1992-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  326-30     Citation Subset:  AIM; IM    
Department of Emergency Medicine, Wilford Hall Medical Center, Lackland Air Force Base, Texas.
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MeSH Terms
Alcoholic Intoxication / complications*
Antacids / therapeutic use
Cardiopulmonary Resuscitation / methods
Charcoal / therapeutic use
Citrates / therapeutic use
Citric Acid
Coronary Disease / chemically induced*,  diagnosis,  therapy
Critical Care
Emergency Service, Hospital
Gastric Lavage
Hydralazine / poisoning*
Poisoning / complications*
Suicide, Attempted
Reg. No./Substance:
0/Antacids; 0/Citrates; 16291-96-6/Charcoal; 77-92-9/Citric Acid; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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