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Acute human parvovirus b19 infection: cytologic diagnosis.
MedLine Citation:
PMID:  25332559     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Human parvovirus B19 is highly tropic to human bone marrow and replicates only in erythroid progenitor cells. It is causative agent of transient aplastic crisis in patients with chronic haemolytic anemia. In immunocompromised patients persistent parvovirus B19 infection may develop and it manifests as pure red cell aplasia and chronic anaemia. Bone marrow is characterised morphologically by giant pronormoblast stage with little or no further maturation. We encountered a case of 6 year old HIV positive male child presented with pure red cell aplasia due to parvovirus B19 infection. Bone marrow aspiration cytology revealed giant pronormoblast with prominent intranuclear inclusions led to suspicion of parvovirus B19 infection which was confirmed by DNA PCR. This case is presented to report classical morphological features of parvovirus B19 infection rarely seen on bone marrow examination should warrant the suspicion of human parvovirus B19 infection in the setting of HIV positive patient with repeated transfusions and confirmation should be done by PCR.
Authors:
Rane Sharada Raju; Kadgi Nalini Vinayak; Vishnuprasad Madhusudan Bapat; Agrawal Preeti Balkisanji; Puranik Shaila Chandrakant
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Publication Detail:
Type:  Journal Article     Date:  2013-09-26
Journal Detail:
Title:  Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion     Volume:  30     ISSN:  0971-4502     ISO Abbreviation:  Indian J Hematol Blood Transfus     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-10-21     Completed Date:  2014-10-21     Revised Date:  2014-10-23    
Medline Journal Info:
Nlm Unique ID:  9425818     Medline TA:  Indian J Hematol Blood Transfus     Country:  India    
Other Details:
Languages:  eng     Pagination:  133-4     Citation Subset:  -    
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