Document Detail

Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor.
MedLine Citation:
PMID:  16618407     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Hepatitis A virus (HAV) infection is the most common cause of acute hepatitis but is rarely reported during pregnancy. Our aim was to evaluate the impact of acute HAV infection on pregnancy outcome. METHODS: Consecutive admissions of 79,458 pregnant females during a 25-year period were retrospectively reviewed. RESULTS: Thirteen cases of second and third trimester HAV infection were found and evaluated. Nine of the 13 patients (69%) developed gestational complications, including premature contractions (n = 4), placental separation (n = 2), premature rupture of membranes (n = 2), and vaginal bleeding (n = 1). In 8 of these patients, complications led to preterm labor, at a median of 34 gestational weeks (range, 31-37 weeks). Delivery was vaginal in 12 of the 13 cases; fetal distress was noted in a single case, and meconium in amniotic fluid in 2 cases. Median birth weight was 1778 grams and 3040 grams in preterm and term deliveries, respectively (P < .05). Child outcome was favorable in all cases. In 4 cases, neonatal serum HAV RNA levels were measured and found negative. The presence of fever and hypoalbuminemia were associated with delivery at an earlier gestational week. There was a positive relation between gestational week at diagnosis of HAV infection and birth week (r = 0.68, P = .02), suggesting a causality relationship. All mothers featured full recovery from HAV infection. CONCLUSIONS: Acute HAV infection during pregnancy is associated with high risk of maternal complications and preterm labor. HAV serology and maternal vaccination during prepregnancy evaluation should be considered in areas of the world in which susceptible adult populations exist.
Eran Elinav; Iddo Z Ben-Dov; Yami Shapira; Nilli Daudi; Ruth Adler; Daniel Shouval; Zvi Ackerman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  130     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2006-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1129-34     Citation Subset:  AIM; IM    
Department of Internal Medicine, Mount Scopus Campus, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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MeSH Terms
Acute Disease
Delivery, Obstetric
Fever / microbiology
Gestational Age
Hepatitis A / blood,  complications*,  diagnosis
Hypoalbuminemia / microbiology
Obstetric Labor, Premature / microbiology*
Pregnancy Complications / microbiology*
Pregnancy Complications, Infectious* / blood,  diagnosis
Pregnancy Outcome
Pregnancy Trimester, Second
Pregnancy Trimester, Third

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