Document Detail

Acute hepatitis associated with treatment of Peyronie's disease with potassium para-aminobenzoate (Potaba).
MedLine Citation:
PMID:  18624965     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Potassium para-aminobenzoate is an agent used in the treatment of sclerotic diseases including Peyronie's disease of the penis. It has been reported that this medication may have been responsible for cases of acute liver injury. AIM: To inform clinicians of the possibility of an adverse drug event associated with the oral intake of potassium para-aminobenzoate by reporting an additional case and compiling information from previous reports. METHODS: The affected patient's medical records were diligently reviewed; all available and relevant information pertaining to this adverse event is reported. Similar case reports were analyzed and compared, and relevant information was compiled in this report. RESULTS: The patient enjoyed a full biochemical recovery from his hepatitis 4 months after discontinuation of potassium para-aminobenzoate. CONCLUSION: To date, the oral use of potassium para-aminobenzoate has been reported to be linked to acute liver injury in six individuals. Appropriate management of this adverse drug event is the immediate discontinuation of the offending drug and general patient support measures.
Joey Roy; Serge Carrier
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-07-01
Journal Detail:
Title:  The journal of sexual medicine     Volume:  5     ISSN:  1743-6109     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-18     Completed Date:  2009-04-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101230693     Medline TA:  J Sex Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2967-9     Citation Subset:  IM    
McGill University, Montreal, Canada.
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MeSH Terms
4-Aminobenzoic Acid / adverse effects*,  therapeutic use
Administration, Oral
Drug-Induced Liver Injury / diagnosis,  etiology*,  therapy
Follow-Up Studies
Liver Function Tests
Penile Induration / drug therapy*
Treatment Outcome
Reg. No./Substance:
150-13-0/4-Aminobenzoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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