Document Detail

Acute hepatitis associated with Barakol.
MedLine Citation:
PMID:  12930029     Owner:  NLM     Status:  MEDLINE    
Barakol is a natural anxiolytic extracted from Cassia siamea, known as "Khi-lek" in Thailand. The authors studied the adverse effects of Barakol in 12 healthy Thai patients, aged 29-81 years (mean 52.5) who took Barakol 3-180 days (mean 76.9). Eight of them were admitted with the first episode of anorexia and jaundice for 4-60 days (mean 14.3) after taking 20-40 mg/day (2-4 tablets) of Barakol. There was no relationship between degree of symptom and dosage/duration of Barakol intake. Three asymptomatic cases were detected with increased aminotransferase from a routine check-up, including an 81 year old female who took half of the dosage for 120 days. The last one was a male patient who presented with low-grade fever and nausea and vomiting. All patients had neither a history of chronic liver disease nor known hepatotoxic substance ingestion. On admission, the mean total bilirubin was 5.7 mg/dl and liver function test (LFT) revealed moderate to severe hepatitis (Aspartate amino transferase (AST) range 111-1,473 U/L: mean = 692). None of them had detected viral markers. Liver biopsy was done in 3 cases and the histopathological findings were compatible with interface hepatitis. Two non-biopsy cases developed recurrent transaminitis after one-week re-challenging without informing the physician. Their symptoms and LFT completely improved within 2-20 weeks (mean 5.9) after Barakol abstinence.
Mongkon Hongsirinirachorn; Sombat Threeprasertsuk; Anuchit Chutaputti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  86 Suppl 2     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-08-21     Completed Date:  2003-10-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  S484-9     Citation Subset:  IM    
Section of Digestive and Liver Diseases, Department of Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.
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MeSH Terms
Acute Disease
Aged, 80 and over
Benzopyrans / adverse effects*
Drug-Induced Liver Injury / diagnosis*,  etiology*,  metabolism
Middle Aged
Retrospective Studies
Reg. No./Substance:
0/Benzopyrans; 0/Phenalenes; 24506-68-1/barakol

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