| Acute hepatitis associated with Barakol. | |
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MedLine Citation:
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PMID: 12930029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Barakol is a natural anxiolytic extracted from Cassia siamea, known as "Khi-lek" in Thailand. The authors studied the adverse effects of Barakol in 12 healthy Thai patients, aged 29-81 years (mean 52.5) who took Barakol 3-180 days (mean 76.9). Eight of them were admitted with the first episode of anorexia and jaundice for 4-60 days (mean 14.3) after taking 20-40 mg/day (2-4 tablets) of Barakol. There was no relationship between degree of symptom and dosage/duration of Barakol intake. Three asymptomatic cases were detected with increased aminotransferase from a routine check-up, including an 81 year old female who took half of the dosage for 120 days. The last one was a male patient who presented with low-grade fever and nausea and vomiting. All patients had neither a history of chronic liver disease nor known hepatotoxic substance ingestion. On admission, the mean total bilirubin was 5.7 mg/dl and liver function test (LFT) revealed moderate to severe hepatitis (Aspartate amino transferase (AST) range 111-1,473 U/L: mean = 692). None of them had detected viral markers. Liver biopsy was done in 3 cases and the histopathological findings were compatible with interface hepatitis. Two non-biopsy cases developed recurrent transaminitis after one-week re-challenging without informing the physician. Their symptoms and LFT completely improved within 2-20 weeks (mean 5.9) after Barakol abstinence. |
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Authors:
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Mongkon Hongsirinirachorn; Sombat Threeprasertsuk; Anuchit Chutaputti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 86 Suppl 2 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-08-21 Completed Date: 2003-10-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: S484-9 Citation Subset: IM |
Affiliation:
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Section of Digestive and Liver Diseases, Department of Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Aged, 80 and over Benzopyrans / adverse effects* Drug-Induced Liver Injury / diagnosis*, etiology*, metabolism Female Humans Male Middle Aged Phenalenes* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Benzopyrans; 0/Phenalenes; 24506-68-1/barakol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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