Document Detail


Acute hemorrhagic edema of infancy (AHEI)--a variant of Henoch-Schönlein purpura or a distinct clinical entity?
MedLine Citation:
PMID:  2229809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute hemorrhagic edema of infancy (AHEI) is an acute cutaneous leukocytoclastic vasculitis (LCV) of infants. The clinical picture has a violent onset with a short benign course followed by spontaneous complete recovery. We report 12 infants with AHEI who were studied clinically, serologically, and immunohistologically. Edema and palpable purpuric skin lesions were present in all infants who were in good general condition. Serologic studies were unremarkable. Light microscopic examination of the skin biopsy specimens revealed LCV as in Henoch-Schönlein purpura (HSP). Direct immunofluorescent study revealed depositions of various immunoreactants, including fibrinogen, C3, IgG, IgM, IgA, and IgE (100%, 100%, 22%, 78%, 33%, and 33%, respectively) in the wall and around the small vessels. Similar deposition of Clq was also present in three infants in whom Clq could be studied (100%). The clinical similarities and differences between AHEI and HSP have been discussed in the literature. AHEI is observed before 2 years of age and is confined to the skin. The skin lesions of HSP are more polymorphic. Although histopathologic findings are similar, the immunohistologic pattern found in our series of AHEI is rather different from the pattern of HSP. Taking all of these findings into account, we suggest that AHEI should be considered as a separate, clinicopathologic entity or a possible variant of HSP. The more descriptive term "acute benign cutaneous LCV of infancy" is offered for this clinicopathologic entity.
Authors:
Y Saraclar; K Tinaztepe; G Adalioğlu; A Tuncer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  86     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-12-04     Completed Date:  1990-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-83     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatric Allergy, Hacettepe University Institute of Child Health and Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Biopsy, Needle
Diagnosis, Differential
Edema / diagnosis*,  immunology,  pathology
Female
Fluorescent Antibody Technique
Hemorrhage / diagnosis*,  immunology,  pathology
Humans
Hypersensitivity / diagnosis,  immunology,  pathology
Immunohistochemistry
Infant
Male
Purpura, Schoenlein-Henoch / diagnosis*,  immunology,  pathology
Serologic Tests
Skin / immunology,  pathology
Skin Diseases / diagnosis*,  immunology,  pathology
Terminology as Topic
Vasculitis / diagnosis,  immunology,  pathology

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