| Acute hemolytic transfusion reaction secondary to anti-Fy3. | |
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MedLine Citation:
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PMID: 15981343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African American woman received two units of RBCs for anemia (Hab 7 g/dL) on admission for a left hip fracture. On hospital Day 7, the patient underwent left hip endoprosthesis surgery; she received two units of RBCs on the second postoperative day due to Hb of 6.1 g/dL. Her urine was dark during surgery and postoperatively. Her posttransfusion plasma was red. Her Hb dropped from 8.4 to 6.4 g/dL over 24 hours after the transfusion. Her total bilirubin rose to 4.0 mg/dL, with and LDH value of 1558 U/L and a haptoglobin of 10.9 mg/dL. Both the antibody detection test and the DAT were positive. An anti-Fy3 was identified in the serum and in the eluate. To the best of our knowledge, this is the first case of acute intravascular hemolysis due to anti-Fy3 in a patient without sickle cell disease. |
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Authors:
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H Olteanu; D Gerber; K Partridge; R Sarode |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Immunohematology / American Red Cross Volume: 21 ISSN: 0894-203X ISO Abbreviation: Immunohematology Publication Date: 2005 |
Date Detail:
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Created Date: 2005-06-27 Completed Date: 2005-09-28 Revised Date: 2008-04-08 |
Medline Journal Info:
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Nlm Unique ID: 8806387 Medline TA: Immunohematology Country: United States |
Other Details:
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Languages: eng Pagination: 48-52 Citation Subset: IM |
Affiliation:
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Department of Pathology, the University of Texas Southwestern Medical Center at Dallas 75390-9073, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Aged, 80 and over Blood Transfusion / adverse effects* Female Hemolysis / immunology* Humans Isoantibodies / blood*, immunology Phenotype |
| Chemical | |
Reg. No./Substance:
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0/Isoantibodies; 0/anti-Fy(a) antibody |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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