Document Detail

Acute hemolytic transfusion reaction secondary to anti-Fy3.
MedLine Citation:
PMID:  15981343     Owner:  NLM     Status:  MEDLINE    
A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African American woman received two units of RBCs for anemia (Hab 7 g/dL) on admission for a left hip fracture. On hospital Day 7, the patient underwent left hip endoprosthesis surgery; she received two units of RBCs on the second postoperative day due to Hb of 6.1 g/dL. Her urine was dark during surgery and postoperatively. Her posttransfusion plasma was red. Her Hb dropped from 8.4 to 6.4 g/dL over 24 hours after the transfusion. Her total bilirubin rose to 4.0 mg/dL, with and LDH value of 1558 U/L and a haptoglobin of 10.9 mg/dL. Both the antibody detection test and the DAT were positive. An anti-Fy3 was identified in the serum and in the eluate. To the best of our knowledge, this is the first case of acute intravascular hemolysis due to anti-Fy3 in a patient without sickle cell disease.
H Olteanu; D Gerber; K Partridge; R Sarode
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Immunohematology / American Red Cross     Volume:  21     ISSN:  0894-203X     ISO Abbreviation:  Immunohematology     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-27     Completed Date:  2005-09-28     Revised Date:  2008-04-08    
Medline Journal Info:
Nlm Unique ID:  8806387     Medline TA:  Immunohematology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  48-52     Citation Subset:  IM    
Department of Pathology, the University of Texas Southwestern Medical Center at Dallas 75390-9073, USA.
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MeSH Terms
Acute Disease
Aged, 80 and over
Blood Transfusion / adverse effects*
Hemolysis / immunology*
Isoantibodies / blood*,  immunology
Reg. No./Substance:
0/Isoantibodies; 0/anti-Fy(a) antibody

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