Document Detail


Acute hemolytic anemia induced by a pyrazolonic drug in a child with glucose-6-phosphate dehydrogenase deficiency.
MedLine Citation:
PMID:  6438997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a 36-month-old child a severe hemolytic anemia occurred after the administration of a pyrazolonic drug. Erythrocyte glucose-6-phosphate dehydrogenase activity was absent in the patient. Intermediate enzymatic levels were demonstrated in the mother and in the maternal grand-mother with a corresponding erythrocyte mosaicism at the methemoglobin elution test. Some cells showed Heinz bodies and peculiar changes in the morphology in the initial phase of the crisis. There is no mention in the literature of a hemolytic action of this drug.
Authors:
G Sansone; S Reali; R Sansone; F Allegranza
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  72     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1984  
Date Detail:
Created Date:  1985-01-24     Completed Date:  1985-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  285-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminopyrine / analogs & derivatives*
Anemia, Hemolytic / chemically induced*
Child, Preschool
Dipyrone / adverse effects*
Erythrocytes / pathology
Glucosephosphate Dehydrogenase Deficiency / blood*,  genetics
Humans
Male
Chemical
Reg. No./Substance:
58-15-1/Aminopyrine; 68-89-3/Dipyrone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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