Document Detail

Acute hemolytic anemia induced by a pyrazolonic drug in a child with glucose-6-phosphate dehydrogenase deficiency.
MedLine Citation:
PMID:  6438997     Owner:  NLM     Status:  MEDLINE    
In a 36-month-old child a severe hemolytic anemia occurred after the administration of a pyrazolonic drug. Erythrocyte glucose-6-phosphate dehydrogenase activity was absent in the patient. Intermediate enzymatic levels were demonstrated in the mother and in the maternal grand-mother with a corresponding erythrocyte mosaicism at the methemoglobin elution test. Some cells showed Heinz bodies and peculiar changes in the morphology in the initial phase of the crisis. There is no mention in the literature of a hemolytic action of this drug.
G Sansone; S Reali; R Sansone; F Allegranza
Related Documents :
24532907 - Local anesthetic systemic toxicity (last) - should we not be concerned?
25245507 - Idiosyncratic drug hepatotoxicity: strategy for prevention and proposed mechanism.
1508427 - Calcium-entry blockers-induced parkinsonism: possible role of inherited susceptibility.
21861867 - Are we ready for therapeutic drug monitoring of biologic therapeutics?
10715697 - Thioridazine treatment modifies the evolution of trypanosoma cruzi infection in mice.
20925437 - Preventability of drug-related harms - part ii: proposed criteria, based on frameworks ...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  72     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1984  
Date Detail:
Created Date:  1985-01-24     Completed Date:  1985-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  285-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aminopyrine / analogs & derivatives*
Anemia, Hemolytic / chemically induced*
Child, Preschool
Dipyrone / adverse effects*
Erythrocytes / pathology
Glucosephosphate Dehydrogenase Deficiency / blood*,  genetics
Reg. No./Substance:
58-15-1/Aminopyrine; 68-89-3/Dipyrone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Adenine arabinoside in severe thrombocytopenia due to hemorrhagic varicella.
Next Document:  Labelled leucine uptake in the visual cells and pigment epithelium of young albino rats in response ...