| Acute hemolysis after receiving oxaliplatin treatment: a case report and literature review. | |
| | |
MedLine Citation:
|
PMID: 19588266 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: To report a case of immune mediated hemolysis occurring after oxaliplatin infusion in a patient with rectal cancer. CASE SUMMARY: We report a 69 year old male patient who presented with acute onset anemia after infusion of oxaliplatin as chemotherapy. A positive direct Coombs test and good response to steroids treatment underlined the diagnosis of immune related hemolytic anemia. The patient was switched to irinotecan-based chemotherapy regimen for further treatment. DISCUSSION: To our knowledge, there has been less than 10 cases of hemolysis occurring after oxaliplatin treatment in the medical literature. In all cases, immune mediated hemolysis has been proven with a positive coombs test. As oxaliplatin based chemotherapy regimen has become a standardized first line treatment for metastatic colorectal adenocarcinoma, this phenomenon warrants a higher level of physician awareness. CONCLUSIONS: Oxaliplatin related hemolytic anemia is a rare reported phenomenon. Patient under oxaliplatin treatment presenting with sudden hemoglobin decrease should prompt further investigation of hemolysis. |
| | |
Authors:
|
Jiun-I Lai; Wei-Shu Wang |
Related Documents
:
|
20476876 - Successful treatment of hereditary factor vii deficiency presented for the first time w... 7263466 - Acute hemolytic anemia, methemoglobinemia, and heinz body formation associated with ing... 1743216 - Transcobalamin ii deficiency: case report and review of the literature. 17889676 - Inherited plasminogen deficiency presenting as ligneous vaginitis: a case report with m... 11653246 - Killing, letting die and the bare difference argument. 12554036 - Reexpansion pulmonary edema: a case report and review of the current literature. |
Publication Detail:
|
Type: Case Reports; Journal Article; Review Date: 2009-07-09 |
Journal Detail:
|
Title: Pharmacy world & science : PWS Volume: 31 ISSN: 1573-739X ISO Abbreviation: Pharm World Sci Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-08-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9307352 Medline TA: Pharm World Sci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 538-41 Citation Subset: IM |
Affiliation:
|
Department of Medicine, National Yang-Ming University Hospital, Yilan, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiple copies of rosR and pssA genes enhance exopolysaccharide production, symbiotic competitivene...
Next Document: Measurement of patient satisfaction with community pharmacy services: a review.