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Acute hemolysis after receiving oxaliplatin treatment: a case report and literature review.
MedLine Citation:
PMID:  19588266     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To report a case of immune mediated hemolysis occurring after oxaliplatin infusion in a patient with rectal cancer. CASE SUMMARY: We report a 69 year old male patient who presented with acute onset anemia after infusion of oxaliplatin as chemotherapy. A positive direct Coombs test and good response to steroids treatment underlined the diagnosis of immune related hemolytic anemia. The patient was switched to irinotecan-based chemotherapy regimen for further treatment. DISCUSSION: To our knowledge, there has been less than 10 cases of hemolysis occurring after oxaliplatin treatment in the medical literature. In all cases, immune mediated hemolysis has been proven with a positive coombs test. As oxaliplatin based chemotherapy regimen has become a standardized first line treatment for metastatic colorectal adenocarcinoma, this phenomenon warrants a higher level of physician awareness. CONCLUSIONS: Oxaliplatin related hemolytic anemia is a rare reported phenomenon. Patient under oxaliplatin treatment presenting with sudden hemoglobin decrease should prompt further investigation of hemolysis.
Authors:
Jiun-I Lai; Wei-Shu Wang
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-07-09
Journal Detail:
Title:  Pharmacy world & science : PWS     Volume:  31     ISSN:  1573-739X     ISO Abbreviation:  Pharm World Sci     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307352     Medline TA:  Pharm World Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  538-41     Citation Subset:  IM    
Affiliation:
Department of Medicine, National Yang-Ming University Hospital, Yilan, Taiwan.
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