Document Detail


Acute hemodynamic effects of pinacidil in hypertensive patients with and without propranolol pretreatment.
MedLine Citation:
PMID:  2037705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the systemic and regional hemodynamic effects of the new antihypertensive agent pinacidil, the authors administered intravenously two doses of pinacidil (0.1 mg/kg) to patients with hypertension after 3 days of randomized, double-blind pretreatment with either propranolol or placebo. Pinacidil administration decreased systemic arterial pressure and total peripheral vascular resistance in both groups of patients. It also decreased pulmonary artery wedge pressure, and increased cardiac output, heart rate, and plasma norepinephrine levels; the changes in cardiac output and heart rate were attenuated by propranolol pretreatment. In addition, propranolol-pretreated patients responded to pinacidil with a decrease in forearm blood flow. In contrast, pinacidil administration exerted no significant effects on right atrial pressure, stroke volume, or mean pulmonary arterial pressure alone or in combination with propranolol. The results show that pinacidil is a potent arterial dilator but has little effect on the venomotor tone in patients with hypertension.
Authors:
C K Stone; K L Wellington; A Willick; J T Sullebarger; C S Liang
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  31     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-28     Completed Date:  1991-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-41     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Rochester Medical Center, New York 14642.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / administration & dosage,  pharmacology*
Double-Blind Method
Female
Forearm / blood supply
Guanidines / administration & dosage,  pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hypertension / drug therapy*
Male
Middle Aged
Pinacidil
Premedication*
Propranolol / pharmacology*
Regional Blood Flow / drug effects
Grant Support
ID/Acronym/Agency:
RR-00045/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Guanidines; 525-66-6/Propranolol; 85371-64-8/Pinacidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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