Document Detail

Acute hemodynamic effects of nitroprusside in children with isolated mitral regurgitation.
MedLine Citation:
PMID:  4025177     Owner:  NLM     Status:  MEDLINE    
The acute hemodynamic responses to nitroprusside during cardiac catheterization were evaluated in 12 children with isolated mitral regurgitation (MR) of congenital origin. The patients were classified into 2 groups. Group I consisted of 5 patients who received digitalis or diuretic drugs and group II consisted of 7 patients who received no medication. Hemodynamic measurements were performed using a multisensor catheter system during infusion of nitroprusside at a dose of 2.0 micrograms/kg/min. With nitroprusside, the mean right atrial pressure decreased an average of 50% in group I (from 6 +/- 1 to 3 +/- 1 mm Hg) and 75% in group II (from 4 +/- 1 to 1 +/- 1 mm Hg), and the mean decrease of pulmonary artery wedge pressure was 50% in group I (from 14 +/- 3 to 7 +/- 3 mm Hg) and 56% in group II (from 9 +/- 2 to 4 +/- 1 mm Hg). Administration of nitroprusside also caused a significant reduction in systemic vascular resistance by 40% in both groups (from 25 +/- 6 to 15 +/- 5 U/m2 in group I and from 25 +/- 2 to 15 +/- 3 3 U/m2 in group II), whereas forward cardiac output increased markedly, by an average of 48% in group I (from 3.3 +/- 0.5 to 4.9 +/- 0.9 liters/min/m2) and 58% in group II (from 3.3 +/- 0.3 to 5.2 +/- 0.8 liters/min/m2). No significant differences in hemodynamic response between groups I and II were noted.(ABSTRACT TRUNCATED AT 250 WORDS)
H Nakano; K Ueda; A Saito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  56     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-08-27     Completed Date:  1985-08-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Flow Velocity
Cardiac Volume / drug effects
Child, Preschool
Ferricyanides / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Mitral Valve Insufficiency / physiopathology*
Nitroprusside / pharmacology*
Pulmonary Wedge Pressure / drug effects
Stroke Volume / drug effects
Time Factors
Vascular Resistance / drug effects
Reg. No./Substance:
0/Ferricyanides; 15078-28-1/Nitroprusside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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