| Acute hemodynamic effects of nitroprusside in children with isolated mitral regurgitation. | |
MedLine Citation:
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PMID: 4025177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute hemodynamic responses to nitroprusside during cardiac catheterization were evaluated in 12 children with isolated mitral regurgitation (MR) of congenital origin. The patients were classified into 2 groups. Group I consisted of 5 patients who received digitalis or diuretic drugs and group II consisted of 7 patients who received no medication. Hemodynamic measurements were performed using a multisensor catheter system during infusion of nitroprusside at a dose of 2.0 micrograms/kg/min. With nitroprusside, the mean right atrial pressure decreased an average of 50% in group I (from 6 +/- 1 to 3 +/- 1 mm Hg) and 75% in group II (from 4 +/- 1 to 1 +/- 1 mm Hg), and the mean decrease of pulmonary artery wedge pressure was 50% in group I (from 14 +/- 3 to 7 +/- 3 mm Hg) and 56% in group II (from 9 +/- 2 to 4 +/- 1 mm Hg). Administration of nitroprusside also caused a significant reduction in systemic vascular resistance by 40% in both groups (from 25 +/- 6 to 15 +/- 5 U/m2 in group I and from 25 +/- 2 to 15 +/- 3 3 U/m2 in group II), whereas forward cardiac output increased markedly, by an average of 48% in group I (from 3.3 +/- 0.5 to 4.9 +/- 0.9 liters/min/m2) and 58% in group II (from 3.3 +/- 0.3 to 5.2 +/- 0.8 liters/min/m2). No significant differences in hemodynamic response between groups I and II were noted.(ABSTRACT TRUNCATED AT 250 WORDS) |
Authors:
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H Nakano; K Ueda; A Saito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 56 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-08-27 Completed Date: 1985-08-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 351-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Cardiac Volume / drug effects Child Child, Preschool Female Ferricyanides / pharmacology* Heart Rate / drug effects Hemodynamics / drug effects* Humans Male Mitral Valve Insufficiency / physiopathology* Nitroprusside / pharmacology* Pulmonary Wedge Pressure / drug effects Stroke Volume / drug effects Time Factors Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Ferricyanides; 15078-28-1/Nitroprusside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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