| Acute hemodynamic effects of insulin-sensitizing agents in isolated perfused rat hearts. | |
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MedLine Citation:
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PMID: 10913592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Troglitazone has direct effects on the hemodynamics of the heart. We investigated the effects of other insulin-sensitizing agents (rosiglitazone, pioglitazone and JTT-501 (4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl]-3, 5-isoxazolidinedione)) on the hemodynamics of the heart using isolated perfused rat hearts. Rosiglitazone significantly decreased heart rate and coronary perfusion pressure, and increased peak isovolumic left ventricular pressure, peak rate of rise of left ventricular pressure and peak rate of fall of left ventricular pressure. The effects of rosiglitazone, however, were milder than those of troglitazone. Neither pioglitazone nor JTT-501 had any effect on the heart. D-alpha-tocopherol, a structural component of troglitazone, did not exert any effect on the heart. The coronary vasorelaxant effect of troglitazone and rosiglitazone was significantly suppressed by indomethacin, but not by N(omega)-nitro-L-arginine methyl ester. In conclusion, only rosiglitazone, as well as troglitazone, exerted positive inotropic, positive lusitropic, negative chronotropic, and coronary vasorelaxant effects on the heart. The coronary vasorelaxant effect of troglitazone and rosiglitazone was mediated by prostaglandin production. |
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Authors:
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K Uchida; K Ogino; M Shimoyama; I Hisatome; C Shigemasa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 400 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-10-12 Completed Date: 2000-10-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 113-9 Citation Subset: IM |
Affiliation:
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First Department of Medicine, Faculty of Medicine, Tottori University, 36-1 Nishimachi, 683-8504, Yonago, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromans / pharmacology Dose-Response Relationship, Drug Hemodynamics / drug effects* Hypoglycemic Agents / pharmacology* Indomethacin / pharmacology Isoxazoles / pharmacology Male NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / physiology Perfusion Prostaglandins / physiology Rats Rats, Wistar Thiazoles / pharmacology Thiazolidinediones* Vitamin E / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Chromans; 0/Hypoglycemic Agents; 0/Isoxazoles; 0/JTT 501; 0/Prostaglandins; 0/Thiazoles; 0/Thiazolidinediones; 10102-43-9/Nitric Oxide; 111025-46-8/pioglitazone; 122320-73-4/rosiglitazone; 1406-18-4/Vitamin E; 50903-99-6/NG-Nitroarginine Methyl Ester; 53-86-1/Indomethacin; 97322-87-7/troglitazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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