Document Detail

Acute hemodynamic effects of induced hypothermia in hemorrhagic shock: an experimental study in the pig.
MedLine Citation:
PMID:  11198359     Owner:  NLM     Status:  MEDLINE    
Hypothermia (HT) is used in certain surgical procedures to reduce metabolism and protect the brain, but in trauma victims accidental HT is considered harmful. Recent animal studies indicate that HT has protective effects in hemorrhagic shock. The aim of the present study was to examine how induced HT modifies the hemodynamic pattern in hemorrhagic shock. Twenty pigs with a body weight of between 17 and 24 kg (mean 20.8) were anesthetized, 50% of their blood volume was withdrawn, and hypothermia (30 degrees C) was induced in half of them (HT group) while the others served as controls. Central hemodynamics was monitored during 4 h via an arterial line and a pulmonary artery catheter. Blood samples were obtained for measurement of leukocyte and platelet counts. Three of the control pigs died while all the animals in the HT group survived the experiment. The hemorrhage resulted in a marked increase in heart rate and a drop in cardiac output and mean arterial pressure. HT slowed the heart rate and induced a further reduction of cardiac output, which parallelled the depression of the core temperature, while the stroke volume did not change in any of the groups. A significant decrease in mean arterial pressure and the leukocyte count became apparent 2 h after the induction of HT. HT aggravated the hypokinetic situation resulting from hemorrhagic shock but without increasing the mortality.
A Wladis; R G Hahn; H Hjelmqvist; B Brismar; B T Kjellström
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  15     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-24     Completed Date:  2001-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  IM    
Department of Surgery, Söder Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Blood Cell Count
Cardiac Output
Heart Rate
Hypothermia, Induced / adverse effects*
Shock, Hemorrhagic / blood,  physiopathology,  therapy*

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