| Acute hemodynamic effects of drugs acting on the renin-angiotensin system in acute heart failure. | |
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MedLine Citation:
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PMID: 7850666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the role of the renin-angiotensin system in a model of acute heart failure. METHODS: Placebo or drugs (Ro 44-9375, a renin inhibitor; captopril, an angiotensin-converting enzyme [ACE] inhibitor; or DuP 532, an angiotensin II receptor [AT1] antagonist) were given to anesthetized splenectomized dogs (n = 12 for each group) for 50 mins after a volume load (dextran 70, 25 mL/kg over 10 mins) during rapid right ventricular pacing at 250 beats/min. Total vascular compliance and capacitance were determined from mean circulatory filling pressure-blood volume curves during transient circulatory arrests induced by acetylcholine. Cardiac index was measured by thermal dilution. RESULTS: Compared with the untreated group, all three drugs significantly reduced systemic pressure and total peripheral resistance while increasing arterial compliance. Captopril alone increased cardiac index (25 +/- 11 versus -23 +/- 13 mL/kg/min) and reduced pulmonary capillary wedge pressure (16.6 +/- 0.7 versus 21.9 +/- 1.0 mmHg). None of the drugs altered the mean circulatory filling pressure, total vascular compliance or capacitance, stressed or unstressed blood volumes, or central blood volume. CONCLUSION: The renin-angiotensin system is not strongly implicated in the hemodynamic manifestations of this model of acute heart failure. These drugs had effects on the arterial but not the venous side of the circulation. Captopril alone reduced pulmonary capillary wedge pressure, perhaps by nonangiotensin effects. |
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Authors:
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A A Nekooeian; R I Ogilvie; D Zborowska-Sluis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 11 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-03-14 Completed Date: 1995-03-14 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
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Clinical Pharmacology Service, Toronto Hospital, Ontario. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Angiotensin-Converting Enzyme Inhibitors / pharmacology, therapeutic use* Animals Blood Pressure / drug effects, physiology Blood Volume / drug effects, physiology Captopril / pharmacology, therapeutic use* Cardiac Output, Low / physiopathology, therapy* Cardiac Pacing, Artificial Dogs Dose-Response Relationship, Drug Female Imidazoles / pharmacology, therapeutic use* Male Receptors, Angiotensin / antagonists & inhibitors* Renin-Angiotensin System / drug effects* Stroke Volume / drug effects, physiology Tetrazoles / pharmacology, therapeutic use* Vascular Resistance / drug effects, physiology Ventricular Function, Left / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Imidazoles; 0/Receptors, Angiotensin; 0/Tetrazoles; 124750-95-4/DuP 532; 143631-62-3/ciprokiren; 62571-86-2/Captopril |
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