Document Detail


Acute haemodynamic effects of metoprolol in hypertensive patients.
MedLine Citation:
PMID:  843419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The acute haemodynamic effects of metoprolol (0.15 mg/kg body weight) intravenously were studied at rest and during exercise, in a recumbent position in five patients with arterial hypertension of WHO Stage 1 or 2. 2. Significant decreases in heart rate, cardiac output and arterial blood pressures, both at rest and during exercise, were seen. There were no changes in the calculated stroke volume or systemic vascular resistance. 3. The apparent absence of any relative preponderance of the alpha-adrenoreceptors after acute beta-adrenoreceptor blockade with metoprolol warrants further studies on metoprolol in arterial hypertension.
Authors:
R Sannerstedt; H Wasir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  4     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hypertension / physiopathology
Male
Metoprolol / pharmacology*
Oxygen Consumption / drug effects
Propanolamines / pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Propanolamines; 37350-58-6/Metoprolol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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