| Acute haemodynamic effects of increase in paced heart rate in heart failure patients recorded with an implantable haemodynamic monitor. | |
| | |
MedLine Citation:
|
PMID: 20952424 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Aims The aim of this study was to investigate the acute effects of different biventricularly paced heart rates (pHRs) on right ventricular (RV) haemodynamics in heart failure (HF) patients with an implantable haemodynamic monitor (IHM). Methods and results At rest, seven pHRs, range 60-120 bpm (steps of 10), were randomly programmed and maintained for 60 s in 10 patients (male, 65 ± 12 years, New York Heart Association II-III). Right ventricular systolic (RVSP) and diastolic pressures, estimated pulmonary artery diastolic (ePAD) pressure, and RV + dP/dt were recorded beat-to-beat using the IHM. Cardiac output (CO) was estimated from the RV pressure waveforms and arterial blood pressure was measured (Portapres(®)). To compare the haemodynamic effects of increased pHR at rest to that of spontaneous, sinus-driven heart rate (HR) increase, patients also performed a symptom-limited bicycle exercise. At rest, RV + dP/dt increased significantly with elevated pHR (P, main effect, <0.001), whereas filling pressures (ePAD and RVSP) decreased significantly in the range 60-100 bpm (P < 0.03 and P < 0.003, respectively) but tended to increase or level out at pHRs >100 bpm. At a pHR of 100 bpm, ePAD was 1.4 mmHg lower compared with 60 bpm (P < 0.01). Cardiac output increased gradually with elevated pHR at rest (P < 0.001). Both total peripheral and estimated pulmonary arterial resistance significantly decreased with increased pHR. During exercise-induced maximum HR increase, RV + dP/dt, ePAD, and CO were all significantly higher compared with the corresponding pHR at rest. Conclusion During cardiac resynchronization therapy in HF patients, the force frequency relationship is present in the RV, as increasing the pHR in the range 60-100 bpm results in decreased filling pressures and increased CO. |
| | |
Authors:
|
Marcus Ståhlberg; Roger Kessels; Cecilia Linde; Frieder Braunschweig |
Related Documents
:
|
6702644 - Right ventricular contractile function in children with congenital heart disease. 8475874 - Morphologic basis for obstruction to right ventricular outflow in hypertrophic cardiomy... 7595124 - Qrst isointegral map reflects the sudden reduction of right ventricular pressure after ... 14551244 - Developmental changes in ventricular diastolic function correlate with changes in ventr... 21942194 - Managing risks from virus intrusion into water distribution systems due to pressure tra... 8162164 - Effect of pericardiocentesis on circulating concentrations of atrial natriuretic hormon... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-14 |
Journal Detail:
|
Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 13 ISSN: 1532-2092 ISO Abbreviation: Europace Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883649 Medline TA: Europace Country: England |
Other Details:
|
Languages: eng Pagination: 237-43 Citation Subset: IM |
Affiliation:
|
1Department of Cardiology, Karolinska Institutet, Karolinska University Hospital, S-17176 Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relaxin family peptides in the male reproductive system--a critical appraisal.
Next Document: Mechanical thrombectomy of an infected deep venous thrombosis: a novel technique of source control i...