Document Detail

Acute haemodynamic effects of erythropoietin alone and in combination with dopamine in a porcine model.
MedLine Citation:
PMID:  16939505     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies in rodents from different kinds of shock models and isolated vessel models indicate that erythropoietin (EPO) has haemodynamic effects through interaction with sympathetic stimuli. This has relevance to the recently described non-haematopoietic effects of EPO, e.g. tissue protective effects. Studies describing the acute effects on integrated physiological haemodynamic variables in larger animal models are scarce though. AIM: To examine the acute effects of EPO on standard physiological haemodynamic parameters as well as a possible synergistic effect of a sympathetic agonist (dopamine) and EPO on these parameters. RESULTS AND DESIGN: A porcine model was applied. Invasive haemodynamic variables were recorded at baseline, during 2 h after EPO injection and with addition of dopamine. Significant changes were only seen with addition of dopamine. Thus cardiac output increased only significantly in control group (21% versus 4%, P<0.05), and accordingly a decline in systemic vascular resistance was only seen in the control group (19% versus 5%, P< 0.05) with addition of dopamine. Pulmonary vascular resistance increased in EPO group (42% versus unchanged, P<0.05). There was a trend towards increase in left ventricular contractility as measured by slope of the pressure-volume relation (E(max)) in EPO group with addition of dopamine. CONCLUSION: Erythropoietin has small but significant haemodynamic effects on the response to a sympathetic agonist in the present minimal invasive porcine model.
Jens Kristensen; Henrik Soegaard; Michael Maeng; Michael Rehling; Torsten Toftegaard Nielsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  26     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-30     Completed Date:  2007-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark.
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MeSH Terms
Cardiac Output
Disease Models, Animal
Dopamine / therapeutic use*
Erythropoietin / therapeutic use*
Models, Cardiovascular
Models, Genetic
Models, Statistical
Oxygen / metabolism
Oxygen Consumption
Shock / therapy*
Time Factors
Reg. No./Substance:
11096-26-7/Erythropoietin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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