Document Detail

Acute haemodynamic effects of dopexamine in patients with coronary arterial disease.
MedLine Citation:
PMID:  1937988     Owner:  NLM     Status:  MEDLINE    
We assessed the acute haemodynamic effects of dopexamine 1 microgram/kg/min and 3 micrograms/kg/min in 21 patients with coronary arterial disease following routine catheterisation. Patients were aged 38 to 72 years and left ventricular ejection fraction ranged from 23 to 79%. Dopexamine was well tolerated in all patients except one in whom transient ventricular arrhythmias occurred with 3 micrograms/kg/min. No patient developed angina. Dopexamine increased cardiac index (2.6 +/- 0.4 to 3.2 +/- 0.1 (P less than 0.001) and 4.0 +/- 1.0 1/min/m2 (P less than 0.001), control to 1 microgram/kg/min and 3 micrograms/kg/min, respectively) and decreased systemic vascular resistance index (3356 +/- 1506 to 2318 +/- 809 (P less than 0.001) and 2252 +/- 1973 (P less than 0.001], but did not affect systemic arterial, pulmonary arterial or right atrial pressure. Maximum positive dP/dt was increased (1294 +/- 324 to 1597 +/- 505 (P less than 0.001) and 2199 +/- 819 mmHg/sec (P less than 0.001] as was left ventricular stroke work index (44 +/- 20 to 51 +/- 21 (P less than 0.05) and 56 +/- 27 g.m/m2 (P less than 0.001) control to 1 microgram/kg/min and 3 micrograms/kg/min, respectively). Left ventricular end diastolic pressure fell with 3 micrograms/kg/min from 19.8 +/- 6.9 to 12.4 +/- 4.6 mmHg (P less than 0.05) in patients with preserved left ventricular ejection fraction (greater than 50%, n = 6), but not in those with impaired left ventricular ejection fraction (less than 50%, n = 15), otherwise the effects in these two subgroups were similar. We conclude that dopexamine has both inotropic and vasodilator properties.(ABSTRACT TRUNCATED AT 250 WORDS)
H Ikram; C J Low; S G Foy; T M Shirlaw; S I Bennett; I G Crozier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  33     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-12-20     Completed Date:  1991-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-104     Citation Subset:  IM    
Department of Cardiology, Princess Margaret Hospital, Christchurch, New Zealand.
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MeSH Terms
Coronary Disease / physiopathology*
Dopamine / analogs & derivatives*,  pharmacology
Heart Catheterization
Hemodynamics / drug effects*
Middle Aged
Vasodilator Agents / pharmacology*
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Vasodilator Agents; 86197-47-9/dopexamine

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