Document Detail

Acute graft-versus-host disease with unusual cutaneous intracellular vacuolation in an infant with severe combined immunodeficiency.
MedLine Citation:
PMID:  8747575     Owner:  NLM     Status:  MEDLINE    
We report an infant with severe combined immunodeficiency (SCID) who had cutaneous manifestations of acute graft-versus-host disease (GVHD) due to maternofetal lymphocyte engraftment. Histologic and ultrastructural examinations of the skin revealed intracellular vacuoles resembling lipid droplets in the epidermis and dermis, which is not a recognized feature of acute GVHD or SCID.
A Farrell; L Scerri; A Stevens; L G Millard
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  12     ISSN:  0736-8046     ISO Abbreviation:  Pediatr Dermatol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-09-17     Completed Date:  1996-09-17     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-3     Citation Subset:  IM    
Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.
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MeSH Terms
Acute Disease
Dermatitis, Exfoliative / complications,  pathology
Graft vs Host Disease / complications*
Keratinocytes / ultrastructure*
Lymphocytes / immunology
Maternal-Fetal Exchange / immunology
Severe Combined Immunodeficiency / complications*
Skin Diseases / complications*,  pathology
Vacuoles / ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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