Document Detail


Acute and genetic toxicity of essential oil extracted from Litsea cubeba (Lour.) Pers.
MedLine Citation:
PMID:  15771186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Litsea cubeba oil is an aromatic essential oil extracted from the fresh fruits of Litsea cubeba (Lour.) Pers. It is used as a flavor enhancer in foods, cosmetics, and cigarettes; as a raw material in the manufacture of citral, vitamins A, E, and K, ionone, methyl ionone, and perfumes; and as an antimicrobial and insecticide. Based on the widespread use of L. cubeba oil, its insolubility in water, resulting in its partition in soil sediment, and its volatility when exposed to the atmosphere, risk of injury due to consumption and occupational exposure may be significant. In the present study, we studied the toxicity of L. cubeba oil with a battery of acute and genetic toxicity tests in Institute of Cancer Research mice and Sprague-Dawley rats. The oral, dermal, and inhalation 50% lethal dose and concentration (LD50 and LC50) of L. cubeba oil were determined. Results indicated that the oral LD50, the dermal LD50, and the inhalation LC50 are approximately 4,000 mg/kg of body weight, in excess of 5,000 mg/kg, and approximatively 12,500 ppm, respectively. We therefore conclude that L. cubeba oil is slightly toxic. In addition, the genetic toxicity of L. cubeba oil was assessed with Salmonella Typhimurium, by determination of the induction of micronuclei in bone marrow cells, and also by testing for chromosome aberration in spermatocyte cells of Institute of Cancer Research mice. The results of genetic toxicity testing of L. cubeba oil in vitro and in vivo were negative.
Authors:
Man Luo; Li-Ke Jiang; Guo-Lin Zou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of food protection     Volume:  68     ISSN:  0362-028X     ISO Abbreviation:  J. Food Prot.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-17     Completed Date:  2005-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703944     Medline TA:  J Food Prot     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-8     Citation Subset:  IM    
Affiliation:
College of Life Sciences, Wuhan University, Wuhan 430072, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Acute Toxicity Tests
Animals
DNA, Bacterial / analysis
Dose-Response Relationship, Drug
Drug Administration Routes
Female
Lethal Dose 50
Litsea / chemistry*
Male
Mice
Mice, Inbred ICR
Micronucleus Tests
Oils, Volatile / toxicity*
Rats
Rats, Sprague-Dawley
Salmonella typhimurium / genetics
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/Oils, Volatile

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