Document Detail

Acute and genetic toxicity of essential oil extracted from Litsea cubeba (Lour.) Pers.
MedLine Citation:
PMID:  15771186     Owner:  NLM     Status:  MEDLINE    
Litsea cubeba oil is an aromatic essential oil extracted from the fresh fruits of Litsea cubeba (Lour.) Pers. It is used as a flavor enhancer in foods, cosmetics, and cigarettes; as a raw material in the manufacture of citral, vitamins A, E, and K, ionone, methyl ionone, and perfumes; and as an antimicrobial and insecticide. Based on the widespread use of L. cubeba oil, its insolubility in water, resulting in its partition in soil sediment, and its volatility when exposed to the atmosphere, risk of injury due to consumption and occupational exposure may be significant. In the present study, we studied the toxicity of L. cubeba oil with a battery of acute and genetic toxicity tests in Institute of Cancer Research mice and Sprague-Dawley rats. The oral, dermal, and inhalation 50% lethal dose and concentration (LD50 and LC50) of L. cubeba oil were determined. Results indicated that the oral LD50, the dermal LD50, and the inhalation LC50 are approximately 4,000 mg/kg of body weight, in excess of 5,000 mg/kg, and approximatively 12,500 ppm, respectively. We therefore conclude that L. cubeba oil is slightly toxic. In addition, the genetic toxicity of L. cubeba oil was assessed with Salmonella Typhimurium, by determination of the induction of micronuclei in bone marrow cells, and also by testing for chromosome aberration in spermatocyte cells of Institute of Cancer Research mice. The results of genetic toxicity testing of L. cubeba oil in vitro and in vivo were negative.
Man Luo; Li-Ke Jiang; Guo-Lin Zou
Related Documents :
21704666 - The effect of pistachio shells as a visual cue in reducing caloric consumption.
12083856 - Detection of hazelnut oil adulteration using ft-ir spectroscopy.
12898646 - Argemone oil induced cellular damage in the reproductive tissues of transgenic drosophi...
17045306 - Microbial community of cyanobacteria mats in the intertidal zone of oil-polluted coast ...
10785526 - Fluoride and magnesium concentrations in human dental calculus obtained from japanese a...
21816446 - Treatment of genetically obese mice with the iminosugar n-(5-adamantane-1-yl-methoxy-pe...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of food protection     Volume:  68     ISSN:  0362-028X     ISO Abbreviation:  J. Food Prot.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-17     Completed Date:  2005-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703944     Medline TA:  J Food Prot     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-8     Citation Subset:  IM    
College of Life Sciences, Wuhan University, Wuhan 430072, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Toxicity Tests
DNA, Bacterial / analysis
Dose-Response Relationship, Drug
Drug Administration Routes
Lethal Dose 50
Litsea / chemistry*
Mice, Inbred ICR
Micronucleus Tests
Oils, Volatile / toxicity*
Rats, Sprague-Dawley
Salmonella typhimurium / genetics
Reg. No./Substance:
0/DNA, Bacterial; 0/Oils, Volatile

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cadmium in cephalopod molluscs: implications for public health.
Next Document:  Feedstock optimization of in-vessel food waste composting systems for inactivation of pathogenic mic...