Document Detail

Acute generalized exanthematic pustulosis: a case and an overview of side effects affecting the skin caused by celecoxib and other COX-2 inhibitors reported so far.
MedLine Citation:
PMID:  15237269     Owner:  NLM     Status:  MEDLINE    
A 55-year-old woman who was treated for periarthritis humeroscapularis with celecoxib (Celebrex) developed a generalized pustular exanthema on the head and upper trunk, accompanied by fever, leukocytosis and increased erythrocyte sedimentation rate. The histological findings were subcorneal pustules, necrotic keratinocytes, edema in the upper dermis and polymorphic perivascular infiltrates. Four days after stopping celecoxib, the pustules disappeared without any treatment. Four weeks after disappearance of the skin lesions, celecoxib demonstrated a positive lymphocyte stimulation test. In this article, we present to our knowledge the first case of acute generalized exanthematic pustulosis caused by celecoxib, and we give an overview of the side effects affecting the skin caused by celecoxib and other cyclooxygenase type 2 inhibitors reported so far.
B Goeschke; L R Braathen
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  209     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-06     Completed Date:  2004-10-07     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Dermatological University Clinic, Inselspital Berne, Berne, Switzerland.
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MeSH Terms
Arthritis / drug therapy
Cyclooxygenase Inhibitors / adverse effects*
Diagnosis, Differential
Drug Eruptions / diagnosis*,  etiology,  pathology
Exanthema / chemically induced,  diagnosis,  pathology
Middle Aged
Sulfonamides / adverse effects*
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Pyrazoles; 0/Sulfonamides; 169590-42-5/celecoxib

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