Document Detail

Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells.
MedLine Citation:
PMID:  20219854     Owner:  NLM     Status:  MEDLINE    
In the central nervous system of mammals, the gene encoding diazepam-binding inhibitor (DBI) is exclusively expressed in glial cells. Previous studies have shown that central administration of a DBI processing product, the octadecaneuropeptide ODN, causes a marked inhibition of food consumption in rodents. Paradoxically, however, the effect of food restriction on DBI gene expression has never been investigated. Here, we show that in mice, acute fasting dramatically reduces DBI mRNA levels in the hypothalamus and the ependyma bordering the third and lateral ventricles. I.p. injection of insulin, but not of leptin, selectively stimulated DBI expression in the lateral ventricle area. These data support the notion that glial cells, through the production of endozepines, may relay peripheral signals to neurons involved in the central regulation of energy homeostasis.
V Comp?re; D Lanfray; H Castel; F Morin; J Leprince; B Dureuil; H Vaudry; G Pelletier; M C Tonon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-10
Journal Detail:
Title:  Journal of molecular endocrinology     Volume:  44     ISSN:  1479-6813     ISO Abbreviation:  J. Mol. Endocrinol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902617     Medline TA:  J Mol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  295-9     Citation Subset:  IM    
Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation University of Rouen, European Institute for Peptide Research (IFRMP 23), Regional Platform for Cell Imaging of Normandy, University of Rouen, 76821 Mont-Saint-Aignan, France.
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MeSH Terms
Diazepam Binding Inhibitor / metabolism*
Ependyma / metabolism
Hypothalamus / metabolism
Injections, Intraperitoneal
Insulin / administration & dosage
Lateral Ventricles / metabolism
Leptin / administration & dosage
Neuroglia / metabolism*
Neuropeptides / genetics,  metabolism*
Peptide Fragments / genetics,  metabolism*
Protein Binding
Third Ventricle / metabolism
Transcription, Genetic
Reg. No./Substance:
0/Diazepam Binding Inhibitor; 0/Leptin; 0/Neuropeptides; 0/Peptide Fragments; 0/diazepam binding inhibitor (33-50); 11061-68-0/Insulin

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