| Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. | |
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MedLine Citation:
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PMID: 12842868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although acute food deprivation and chronic food restriction both result in body weight loss, they produce different metabolic states. To evaluate how these two treatments affect hypothalamic peptide systems involved in energy homeostasis, we compared patterns of hypothalamic neuropeptide Y (NPY), agouti-related protein (AgRP), proopiomelanocotin (POMC), and leptin receptor gene expression in acutely food-deprived and chronically food-restricted rats. Both acute food deprivation and chronic food restriction reduced body weight and circulating leptin levels and resulted in increased arcuate NPY and decreased arcuate POMC gene expression. Arcuate AgRP mRNA levels were only elevated in acutely deprived rats. NPY gene expression was increased in the compact subregion of the dorsomedial hypothalamus (DMH) in response to chronic food restriction, but not in response to acute food deprivation. Leptin receptor expression was not affected by either treatment. Double in situ hybridization histochemistry revealed that, in contrast to the situation in the arcuate nucleus, NPY and leptin receptor mRNA-expressing neurons were not colocalized in the DMH. Together, these data suggest that arcuate and DMH NPY gene expression are differentially regulated. DMH NPY-expressing neurons do not appear to be under the direct control of leptin signaling. |
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Authors:
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Sheng Bi; Benjamin M Robinson; Timothy H Moran |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-07-03 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 285 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-14 Completed Date: 2003-11-21 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1030-6 Citation Subset: IM |
Affiliation:
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Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins Univ. School of Medicine, 720 Rutland Ave., Ross 618, Baltimore, MD 21205, USA. sbi@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Agouti-Related Protein Animals Blood Glucose / metabolism Body Weight / physiology Dorsomedial Hypothalamic Nucleus / physiology* Energy Intake / physiology* Food Deprivation / physiology* Gene Expression / physiology Insulin / blood Intercellular Signaling Peptides and Proteins Leptin / blood Male Neuropeptide Y / genetics* Pro-Opiomelanocortin / genetics Proteins / genetics RNA, Messenger / analysis Rats Rats, Sprague-Dawley Receptors, Cell Surface / genetics Receptors, Leptin |
| Grant Support | |
ID/Acronym/Agency:
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DK-19302/DK/NIDDK NIH HHS; DK-57609/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/AGRP protein, rat; 0/Agouti-Related Protein; 0/Blood Glucose; 0/Intercellular Signaling Peptides and Proteins; 0/Leptin; 0/Neuropeptide Y; 0/Proteins; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 11061-68-0/Insulin; 66796-54-1/Pro-Opiomelanocortin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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