Document Detail


Acute flaccid paralysis associated with West Nile virus: motor and functional improvement in 4 patients.
MedLine Citation:
PMID:  15605329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe motor and functional recovery in 4 patients with acute flaccid paralysis associated with West Nile virus (WNV) infection. DESIGN: A case series describing patient clinical features at admission to rehabilitation through 6-month follow-up. SETTING: Academic acute free-standing inpatient rehabilitation hospital. PARTICIPANTS: The patients (3 men, 1 woman; age range, 29-72 y) with central nervous system WNV infection presented on rehabilitation admission, 18 to 112 days after onset of symptoms, with severe flaccid asymmetric weakness without sensory loss, and decreased functional independence. Electrodiagnostic studies demonstrated a severe diffuse motor axonopathy consistent with an anterior myelitis. INTERVENTION: Acute inpatient rehabilitation program over a period of 35 to 106 days. MAIN OUTCOME MEASURES: Motor and FIM instrument scores at admission to rehabilitation, discharge, and 6-month follow-up. RESULTS: All patients showed modest improvements in strength and function; no patient made full recovery of strength or became ambulatory by 6-month follow-up. CONCLUSIONS: Little is known about recovery in patients with WNV-associated anterior myelitis. It will be important to document any further improvements in strength and function in such patients over a longer follow-up period.
Authors:
Christina Marciniak; Susan Sorosky; Christina Hynes
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  85     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-17     Completed Date:  2005-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1933-8     Citation Subset:  AIM; IM    
Affiliation:
Northwestern University, Feinberg School of Medicine and the Rehabilitation Institute of Chicago, Chicago, IL 60611, USA. cmarciniak@ric.org
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living
Adult
Aged
Axons / physiology
Disability Evaluation
Electrodiagnosis
Electromyography
Female
Humans
Male
Middle Aged
Motor Neurons / physiology
Myelitis / physiopathology,  virology
Neural Conduction / physiology
Paralysis / physiopathology,  rehabilitation*,  virology*
Recovery of Function / physiology
West Nile Fever / physiopathology*
West Nile virus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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