Document Detail

Acute fibrinous and organizing pneumonia in systemic lupus erythematosus: a case report and review of the literature.
MedLine Citation:
PMID:  20946526     Owner:  NLM     Status:  MEDLINE    
Pulmonary manifestations of systemic lupus erythematosus (SLE) typically include pleuritis, alveolar hemorrhage, and infectious pneumonia due to immunosuppression with less common entities including bronchiolitis, interstitial pneumonia, and pulmonary fibrosis. More rare manifestations include organizing pneumonia (OP) and diffuse alveolar damage (DAD). A similar but distinct entity of acute fibrinous and organizing pneumonia (AFOP), characterized by intra-alveolar fibrin deposition and associated organizing pneumonia, has been reported in association with connective tissue disorders, but has not been described in association with SLE. Reported herein is a patient with SLE and accompanying antiphospholipid syndrome with recent pulmonary embolism, persistent respiratory symptomology, and persistent radiographic abnormalities who underwent lung biopsy displaying features of AFOP. This case in conjunction with previous literature indicates that AFOP can be a manifestation of connective tissue disease including SLE and may be an underreported variant of medical lung disease due to overlap in histological characteristics with OP and DAD.
Lida P Hariri; Sebastian Unizony; John Stone; Mari Mino-Kenudson; Amita Sharma; Osamu Matsubara; Eugene J Mark
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-08-13
Journal Detail:
Title:  Pathology international     Volume:  60     ISSN:  1440-1827     ISO Abbreviation:  Pathol. Int.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  755-9     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
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MeSH Terms
Antiphospholipid Syndrome / complications,  pathology,  radiography
Lung / pathology*,  radiography
Lupus Erythematosus, Systemic / complications*,  pathology,  radiography
Middle Aged
Pneumonia / complications*,  pathology,  radiography
Pulmonary Fibrosis / complications,  pathology*,  radiography

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