Document Detail

Acute fetal asphyxia and permanent brain injury: a retrospective analysis of current indicators.
MedLine Citation:
PMID:  10338063     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether a term neonate who has had sufficient intrapartum asphyxia to produce persistent brain injury will manifest the following four criteria: profound acidemia (arterial pH <7.00), an APGAR score < or =3 for 5 min or longer, seizures within 24 h of birth, and multiorgan system dysfunction. METHODS: Singleton, liveborn, neurologically impaired neonates > or =37 weeks gestation who lived at least 6 days and had sufficient documentation of current intrapartum asphyxia criteria were retrospectively analyzed. Of these infants, solely neonates with acute fetal asphyxia due to a sudden prolonged FHR deceleration that lasted until delivery from a catastrophic event, e.g., uterine rupture, cord prolapse, were included. Organ system dysfunction was defined by separate criteria for each organ system. Dysfunction in one or more was defined as multiorgan system dysfunction. RESULTS: Of the 292 eligible infants in the registry, 47 satisfied the entry criteria. In these 47 neonates, 10 (21%) satisfied all 4 criteria for intrapartum asphyxia. CONCLUSIONS: Our retrospective study suggests that currently used indicators to define permanent fetal brain injury are not valid.
L M Korst; J P Phelan; Y M Wang; G I Martin; M O Ahn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of maternal-fetal medicine     Volume:  8     ISSN:  1057-0802     ISO Abbreviation:  J Matern Fetal Med     Publication Date:    1999 May-Jun
Date Detail:
Created Date:  1999-07-01     Completed Date:  1999-07-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9211288     Medline TA:  J Matern Fetal Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
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MeSH Terms
Apgar Score
Asphyxia Neonatorum / complications*
Brain Injuries / diagnosis*,  etiology*
Cerebral Palsy / etiology
Fetal Blood
Gestational Age
Heart Rate, Fetal
Hydrogen-Ion Concentration
Infant, Newborn
Lung Diseases / etiology
Retrospective Studies

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