Document Detail


Acute felbamate overdose with crystalluria.
MedLine Citation:
PMID:  15902793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 3-year-old child developed vomiting, ataxia, and crystalluria after ingestion of approximately 232 mg/kg of felbamate elixir. High-powered polarization microscopy of the urine revealed sharp, needle-like crystals. The analysis of the urine crystals showed unchanged felbamate (80.9%), monocarbamate felbamate (18.8%), and trace amounts of mercapturic acid conjugates of the metabolite 2-phenylpropenal (0.1%). The serum felbamate level 15 h after ingestion was 138 mg/L. Crystalluria and hematuria resolved with intravenous fluid therapy, and the child recovered within 24 h.
Authors:
Kathryn H Meier; Kent R Olson; Jean L Olson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical toxicology (Philadelphia, Pa.)     Volume:  43     ISSN:  1556-3650     ISO Abbreviation:  Clin Toxicol (Phila)     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-20     Completed Date:  2005-06-02     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101241654     Medline TA:  Clin Toxicol (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  AIM; IM    
Affiliation:
California Poison Control System, Department of Clinical Pharmacy, University of California, San Francisco, CA 94143-1369, USA. kmpcc@itsa.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / blood,  poisoning*
Child, Preschool
Crystallization
Female
Fluid Therapy / methods
Humans
Infusions, Intravenous
Microscopy, Polarization
Overdose
Phenylcarbamates
Poisoning / etiology*,  therapy,  urine
Propylene Glycols / analysis,  blood,  poisoning*
Treatment Outcome
Urinary Calculi / etiology*,  pathology,  urine
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Phenylcarbamates; 0/Propylene Glycols; 25451-15-4/felbamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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