| Acute fatty liver of pregnancy: an update on pathogenesis and clinical implications. | |
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MedLine Citation:
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PMID: 17167825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute fatty liver of pregnancy (AFLP) is a serious maternal illness occurring in the third trimester of pregnancy with significant perinatal and maternal mortality. Till recently, it has been considered a mysterious illness. In this editorial, we review the recent advances in understanding the pathogenesis of AFLP and discuss the studies documenting a fetal-maternal interaction with a causative association between carrying a fetus with a defect in mitochondrial fatty acid oxidation and development of AFLP. Further, we discuss the impact of these recent advances on the offspring born to women who develop AFLP, such that screening for a genetic defect can be life saving to the newborn and would allow genetic counseling in subsequent pregnancies. The molecular basis and underlying mechanism for this unique fetal-maternal interaction causing maternal liver disease is discussed. |
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Authors:
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Jamal-A Ibdah |
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Publication Detail:
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Type: Editorial; Review |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 12 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-14 Completed Date: 2007-01-31 Revised Date: 2012-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 7397-404 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Fatty Acids / metabolism Fatty Liver / complications*, diagnosis, etiology Female HELLP Syndrome / diagnosis Humans Infant, Newborn Lipid Metabolism, Inborn Errors / complications, diagnosis Maternal-Fetal Exchange Mitochondrial Diseases / complications, diagnosis, genetics Multienzyme Complexes / genetics, metabolism Oxidation-Reduction Pregnancy Pregnancy Complications* / diagnosis, etiology |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Multienzyme Complexes; 0/mitochondrial fatty acid beta-oxidation trifunctional protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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