Document Detail

Acute fatty liver of pregnancy: an update on pathogenesis and clinical implications.
MedLine Citation:
PMID:  17167825     Owner:  NLM     Status:  MEDLINE    
Acute fatty liver of pregnancy (AFLP) is a serious maternal illness occurring in the third trimester of pregnancy with significant perinatal and maternal mortality. Till recently, it has been considered a mysterious illness. In this editorial, we review the recent advances in understanding the pathogenesis of AFLP and discuss the studies documenting a fetal-maternal interaction with a causative association between carrying a fetus with a defect in mitochondrial fatty acid oxidation and development of AFLP. Further, we discuss the impact of these recent advances on the offspring born to women who develop AFLP, such that screening for a genetic defect can be life saving to the newborn and would allow genetic counseling in subsequent pregnancies. The molecular basis and underlying mechanism for this unique fetal-maternal interaction causing maternal liver disease is discussed.
Jamal-A Ibdah
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Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  12     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-14     Completed Date:  2007-01-31     Revised Date:  2014-09-07    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  7397-404     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Fatty Acids / metabolism
Fatty Liver / complications*,  diagnosis,  etiology
HELLP Syndrome / diagnosis
Infant, Newborn
Lipid Metabolism, Inborn Errors / complications,  diagnosis
Maternal-Fetal Exchange
Mitochondrial Diseases / complications,  diagnosis,  genetics
Mitochondrial Trifunctional Protein
Multienzyme Complexes / genetics,  metabolism
Pregnancy Complications* / diagnosis,  etiology
Reg. No./Substance:
0/Fatty Acids; 0/Multienzyme Complexes; EC Trifunctional Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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