| Acute fatty liver of pregnancy in 3 tertiary care centers. | |
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MedLine Citation:
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PMID: 15902124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to determine the demographics, clinical presentation, and maternal and neonatal outcomes in patients who were diagnosed with acute fatty liver of pregnancy over a 10-year period. STUDY DESIGN: This was a multicenter retrospective study of women with the diagnosis of acute fatty liver of pregnancy. Records were reviewed for symptoms, laboratory findings, clinical course, and maternal and perinatal outcomes. RESULTS: Sixteen cases of acute fatty liver of pregnancy were identified. Three of the 16 cases had multiple gestations (18%). Eleven of the 16 cases were diagnosed in the antepartum period, and 5 cases were diagnosed within 4 days after delivery. Nausea and vomiting were the most common symptoms (75%). There were 2 maternal deaths (12.5%) and 3 fetal deaths (15%). CONCLUSION: We recommend that patients with persistent nausea, vomiting, or epigastric pain in the third trimester receive evaluation of liver enzymes, renal function, and a complete blood count to rule out the diagnosis of acute fatty liver of pregnancy. |
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Authors:
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Michael F Fesenmeier; Kristin H Coppage; Donna S Lambers; John R Barton; Baha M Sibai |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 192 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-19 Completed Date: 2005-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1416-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Cincinnati, Ohio 45267-0526, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Fatty Liver* / complications, diagnosis, epidemiology Female Fetal Mortality Gestational Age Humans Incidence Postpartum Period Pregnancy Pregnancy Complications* / diagnosis, epidemiology, mortality Pregnancy Outcome Pregnancy, Multiple Retrospective Studies |
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