Document Detail


Acute fatty liver of pregnancy: diagnosis, treatment, and outcome based on 35 consecutive cases.
MedLine Citation:
PMID:  21668324     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. We describe our experience with the clinical diagnosis, management and, course of patients with acute fatty liver of pregnancy (AFLP). Methods. During the period between January 1996 and June 2010, medical records of patients with AFLP were reviewed for symptoms, laboratory findings, clinical course, and maternal and perinatal outcomes. Routine laboratory evaluation included serial measurement of liver function tests, complete blood cell counts, coagulation profile, and renal function tests. Results. During the study period 35 women had AFLP as the discharge diagnosis. The mean gestational age at delivery was 36 weeks, 39% were nulliparous and 4 had multiple gestation. The most common presenting symptom was nausea/vomiting (88.5%), jaundice (71.4%), and abdominal pain (51.4%). Maternal morbidity included hypoglycemia (94.2%), renal failure (94.2%), coagulopathy (77.1%), ascites (48.5%), and encephalopathy (40%). There were four maternal deaths (11.4%) and five perinatal deaths (12.5%). Conclusion. We found a typical 'AFLP-Triad' in women with AFLP. First (symptoms): nausea/vomiting, jaundice, epigastric pain; second (laboratory): results indicated renal dysfunction, coagulopathy, liver function abnormalities, low glycemia, and third (complications): renal failure, coagulopathy, ascites, and encephalopathy. We recommended that patients with this triad received evaluation to rule out the diagnosis of AFLP.
Authors:
Paulino Vigil-de Gracia; Carlos Montufar-Rueda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Critical Care Unit, Department of Obstetrics and Gynecology, Social security, Panama, Panama.
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