| Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report. | |
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MedLine Citation:
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PMID: 12170538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute fatty liver of pregnancy is a rare entity. A MEDLINE English-language search from 1966 to the present revealed no reports of acetaminophen toxicity and acute fatty liver in pregnancy. CASE: An 18-year-old, African American woman, gravida 1, presented at 33 weeks' gestation with signs and symptoms consistent with acute fatty liver of pregnancy and fetal death. Markedly elevated transaminases prompted a search for other etiologies, and acetaminophen toxicity was diagnosed. Liver biopsy revealed acute fatty liver of pregnancy and toxin-induced injury consistent with acetaminophen use. The patient's condition deteriorated, resulting in fulminant hepatic failure and requiring postpartum orthotopic liver transplantation. CONCLUSION: The combination of acute fatty liver of pregnancy and acetaminophen toxicity resulted in acute liver failure. Attention to clinical and biochemical parameters can lead to diagnosis and management. |
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Authors:
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Edward J Gill; Melissa J Contos; Thomas C C Peng |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 47 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-08-12 Completed Date: 2003-01-23 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 584-6 Citation Subset: IM |
Affiliation:
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Departments of Obstetrics and Gynecology and of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA. egill@hsc.vcu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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adverse effects* Adolescent Analgesics, Non-Narcotic / adverse effects* Diagnosis, Differential Drug-Induced Liver Injury / diagnosis*, etiology, pathology, therapy Female Fetal Death / diagnosis Humans Liver Failure / chemically induced, diagnosis*, pathology, therapy Liver Transplantation* Postpartum Period Pregnancy Pregnancy Complications / chemically induced, diagnosis*, pathology, therapy Pregnancy Trimester, Third |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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