Document Detail


Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report.
MedLine Citation:
PMID:  12170538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acute fatty liver of pregnancy is a rare entity. A MEDLINE English-language search from 1966 to the present revealed no reports of acetaminophen toxicity and acute fatty liver in pregnancy. CASE: An 18-year-old, African American woman, gravida 1, presented at 33 weeks' gestation with signs and symptoms consistent with acute fatty liver of pregnancy and fetal death. Markedly elevated transaminases prompted a search for other etiologies, and acetaminophen toxicity was diagnosed. Liver biopsy revealed acute fatty liver of pregnancy and toxin-induced injury consistent with acetaminophen use. The patient's condition deteriorated, resulting in fulminant hepatic failure and requiring postpartum orthotopic liver transplantation. CONCLUSION: The combination of acute fatty liver of pregnancy and acetaminophen toxicity resulted in acute liver failure. Attention to clinical and biochemical parameters can lead to diagnosis and management.
Authors:
Edward J Gill; Melissa J Contos; Thomas C C Peng
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  47     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-12     Completed Date:  2003-01-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  584-6     Citation Subset:  IM    
Affiliation:
Departments of Obstetrics and Gynecology and of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA. egill@hsc.vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / adverse effects*
Adolescent
Analgesics, Non-Narcotic / adverse effects*
Diagnosis, Differential
Drug-Induced Liver Injury / diagnosis*,  etiology,  pathology,  therapy
Female
Fetal Death / diagnosis
Humans
Liver Failure / chemically induced,  diagnosis*,  pathology,  therapy
Liver Transplantation*
Postpartum Period
Pregnancy
Pregnancy Complications / chemically induced,  diagnosis*,  pathology,  therapy
Pregnancy Trimester, Third
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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