Document Detail

Acute fatal vasoplegia and asystole induced by intravenous amiodarone after cardiopulmonary bypass in a patient with preoperative cardiogenic shock.
MedLine Citation:
PMID:  10670119     Owner:  NLM     Status:  MEDLINE    
Single dose intravenous amiodarone has been widely used and shown to be effective to treat supraventricular and ventricular arrhythemias in cardiac surgery. We, herein, report a 60-year-old female patient, sustaining cardiogenic shock in the course of percutaneous transluminal coronary angioplasty (PTCA) for unstable angina unrelieved by medication including nitroglycerin, succumbed to a life-saving emergent coronary artery bypass grafting (CABG) operation at the end of cardiopulmonary bypass (CPB) following a 180 mg bolus dose of amiodarone (3 mg/kg) directed at the ventricular arrhythmias, triggered by protamine and unresponsive to lidocaine treatment. Amiodaroneinduced asystole and vasoplegia were thought to be the causation of the failure of resuscitation. The causes of the development of these complications, the potential hazards of its use and the management relative to the consequential complications are reviewed and discussed.
J P Shieh; C C Chu; J Y Chen; Y H Chen; F C Yeh; C H Hsing
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Sinica     Volume:  37     ISSN:  0254-1319     ISO Abbreviation:  Acta Anaesthesiol. Sin.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-24     Completed Date:  2000-02-24     Revised Date:  2014-07-14    
Medline Journal Info:
Nlm Unique ID:  9432542     Medline TA:  Acta Anaesthesiol Sin     Country:  CHINA (REPUBLIC: 1949- )    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
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MeSH Terms
Amiodarone / adverse effects*
Anti-Arrhythmia Agents / adverse effects*
Cardiopulmonary Bypass / adverse effects*
Fatal Outcome
Heart Arrest / chemically induced*
Middle Aged
Shock, Cardiogenic / complications
Vasodilation / drug effects*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; N3RQ532IUT/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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