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Acute exposure to tributyltin induces c-fos activation in the hypothalamic arcuate nucleus of adult male mice.
MedLine Citation:
PMID:  21185327     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tributyltin (TBT) is a largely diffused environmental pollutant, banned from paints in the European Union from 2003. However, the level of TBT (and other organotins) in food, particularly fish and shellfish, remains still high. Several studies demonstrated that TBT is involved in the development of obesity, via peripheral action, but currently, there are only a few data illustrating effects of TBT on the nervous system. In the present study, we tested the hypothesis that acute exposure to TBT may directly activate brain cells in particular, in those hypothalamic nuclei regulating the food intake. To this purpose, TBT was orally administered at a single dose (10mg/kg/body weight) to two groups of adult male mice: regularly fed or fasted for 24h. Mice were sacrificed 90min after the TBT administration and perfused by 4% paraformaldehyde. Brains were quickly dissected, frozen and sectioned for immunocytochemical detection of c-fos, a common marker of cell activation. In both, fed or fasted mice, exposure to TBT induced a significant increase of c-fos expression in the arcuate nucleus in comparison to control mice. The other nuclei involved in the control of feeding behavior did not show any significant increase. These data are the first in vivo demonstration that TBT has not only peripheral effects, but also may activate elements in the brain, in particular in a crucial region for the regulation of food intake like the arcuate nucleus.
Authors:
E Bo; C Viglietti-Panzica; G C Panzica
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-23
Journal Detail:
Title:  Neurotoxicology     Volume:  -     ISSN:  1872-9711     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Laboratory of Neuroendocrinology, Neuroscience Institute of Torino (NIT), National Institute of Neuroscience (INN, Torino), Dept. Anatomy, Pharmacology and Forensic Medicine, University of Torino, corso M. D'Azeglio 52, 10126 Torino, Italy; Neuroscience Institute Cavalieri-Ottolenghi (NICO), Regione Gonzole, 10 - 10043 Orbassano (TO), Italy.
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