| Acute exposure to long-chain fatty acids impairs {alpha}2-adrenergic receptor-mediated antilipolysis in human adipose tissue. | |
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MedLine Citation:
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PMID: 17625217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute in vitro and in vivo effects of long-chain fatty acids (LCFAs) on the regulation of adrenergic lipolysis were investigated in human adipose tissue. The effect of a 2 h incubation, without or with LCFA (200 mumol/l), on basal and hormonally induced lipolysis was tested in vitro on isolated fat cells. The lipolytic response to epinephrine was enhanced by suppression of the antilipolytic alpha(2)-adrenergic effect. Then, healthy lean and obese male subjects performed a 45 min exercise bout at 50% of their heart rate reserve either after an overnight fast or 3 h after a high-fat meal (HFM: 95% fat, 5% carbohydrates). Subcutaneous adipose tissue lipolysis was measured by microdialysis in the presence or absence of an alpha-antagonist (phentolamine). In vivo, a HFM increased plasma levels of nonesterified fatty acids in lean and obese subjects. In both groups, the HFM did not alter hormonal responses to exercise. Under fasting conditions, the alpha(2)-adrenergic antilipolytic effect was more pronounced in obese than in lean subjects. The HFM totally suppressed the alpha(2)-adrenergic antilipolytic effect in lean and obese subjects during exercise. LCFAs per se, in vitro as well as in vivo, suppress alpha(2)-adrenergic-mediated antilipolysis in adipose tissue. LCFA-mediated suppression of antilipolytic pathways represents another mechanism whereby a high fat content in the diet might increase adipose tissue lipolysis. |
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Authors:
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Jan Polak; Cédric Moro; David Bessière; Jindra Hejnova; Marie A Marquès; Magda Bajzova; Max Lafontan; Francois Crampes; Michel Berlan; Vladimir Stich |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-11 |
Journal Detail:
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Title: Journal of lipid research Volume: 48 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-17 Completed Date: 2007-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
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Languages: eng Pagination: 2236-46 Citation Subset: IM |
Affiliation:
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Franco-Czech Laboratory for Clinical Research on Obesity, French Institute of Health and Medical Research (Institut National de la Santé et de la Recherche Médicale U858), Charles University in Prague, Prague, Czech Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Adult Dietary Fats* Fatty Acids / metabolism* Female Food Humans Insulin / metabolism Lipolysis Male Microdialysis Middle Aged Obesity Phentolamine / pharmacology Receptors, Adrenergic, alpha-2 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Receptors, Adrenergic, alpha-2; 11061-68-0/Insulin; 50-60-2/Phentolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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