Document Detail


Acute exposure to acid fog. Effects on mucociliary clearance.
MedLine Citation:
PMID:  8484617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Submicrometric sulfuric acid (H2SO4) aerosol can affect mucociliary clearance without eliciting irritative symptoms or changes in pulmonary function. The effect of larger fog droplets containing H2SO4 on mucociliary clearance is unknown. We quantified mucociliary clearance from the trachea (n = 4) and small airways (n = 7) of young healthy male adults after an acute exposure to H2SO4 fog (MMAD = 10.3 microns; pH = 2.0; liquid water content = 481 +/- 65 mg/m3; osmolarity = 30 mOsm). Acid fog (AF) or saline fog (SF) (10.9 microns; 492 +/- 116 mg/m3; 30 mOsm) was administered for 40 min of unencumbered breathing (no mouth-piece) at rest and for 20 min of exercise sufficient to produce oronasal breathing. Fog exposures were followed by a methacholine (MCh) challenge (a measure of airway reactivity) or inhalation of technetium-99M radioaerosol (MMAD = 3.4 microns) on 2 study days each. Changes in symptoms and forced ventilatory function were also assessed. Clearance was quantified from computer-assisted analyses of gamma camera images of the lower respiratory tract in terms of %removal/min of the radiolabel from the trachea 25 min after inhalation and from the outer zone of the right lung after 1.9 to 3 h. Symptoms, forced ventilatory function, and MCh response were unaffected by either fog. Tracheal clearance was more rapid in four of four subjects after AF (0.83 +/- 1.58% removal/min) compared with that after SF (-0.54 +/- 0.85% removal/min). Outer zone clearance was more rapid in six of seven subjects after AF (0.22 +/- 0.15% removal/min) compared with that after SF (0.01 +/- 0.09% removal/min).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
B L Laube; S M Bowes; J M Links; K K Thomas; R Frank
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  147     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-03     Completed Date:  1993-06-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1105-11     Citation Subset:  AIM; IM    
Affiliation:
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aerosols
Air Pollutants / pharmacology*
Bronchi / physiology
Bronchial Provocation Tests
Humans
Hydrogen-Ion Concentration
Male
Methacholine Chloride / diagnostic use
Mucociliary Clearance / drug effects*
Particle Size
Respiratory Mechanics / drug effects
Sulfuric Acids / pharmacology*
Trachea / physiology
Weather
Grant Support
ID/Acronym/Agency:
ES-03819/ES/NIEHS NIH HHS; ES-03871/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Aerosols; 0/Air Pollutants; 0/Sulfuric Acids; 62-51-1/Methacholine Chloride; 7664-93-9/sulfuric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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