Document Detail

Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae.
MedLine Citation:
PMID:  22833361     Owner:  NLM     Status:  Publisher    
The aim of the present study was to investigate the acute developmental neurotoxicity of polybrominated diphenyl ethers (PBDEs) in zebrafish larvae. From 2 to 120 h postfertilization Zebrafish embryos at were exposed to DE-71 (0, 31.0, 68.7, and 227.6 µg/L). We studied the locomotor behavior of larvae, involvement of the cholinergic system, and selected gene and protein expressions in the central nervous system. Our results showed that low DE-71 concentration caused hyperactivity, whereas higher concentrations decreased activity during the dark period. During the light period, larval activity was significantly reduced in a concentration-dependent manner. In the cholinergic system, acetylcholinesterase activity significantly increased (10.7and 12.4%) in the 68.7 and 227.6 µg/L exposure groups, respectively, and acetylcholine concentration accordingly decreased (60.5%) in the 227.6 µg/L exposure group. The mRNA expressions of genes encoding myelin basic protein, neuron microtubule protein (α1-tubulin), and sonic hedgehog a were significantly downregulated. Western blotting assay demonstrated that the protein concentration of α1-tubulin was also decreased. Overall, this study demonstrated that acute exposure to PBDEs can disrupt the neurobehavior of zebrafish larvae and affect cholinergic neurotransmission and neuron development. Environ. Toxicol. Chem. © 2012 SETAC.
Lianguo Chen; Changjiang Huang; Chenyan Hu; Ke Yu; Lihua Yang; Bingsheng Zhou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-25
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  -     ISSN:  1552-8618     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 SETAC.
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; Graduate School of the Chinese Academy of Sciences, Beijing, China.
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