| Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. | |
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MedLine Citation:
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PMID: 22833361 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of the present study was to investigate the acute developmental neurotoxicity of polybrominated diphenyl ethers (PBDEs) in zebrafish larvae. From 2 to 120 h postfertilization Zebrafish embryos at were exposed to DE-71 (0, 31.0, 68.7, and 227.6 µg/L). We studied the locomotor behavior of larvae, involvement of the cholinergic system, and selected gene and protein expressions in the central nervous system. Our results showed that low DE-71 concentration caused hyperactivity, whereas higher concentrations decreased activity during the dark period. During the light period, larval activity was significantly reduced in a concentration-dependent manner. In the cholinergic system, acetylcholinesterase activity significantly increased (10.7and 12.4%) in the 68.7 and 227.6 µg/L exposure groups, respectively, and acetylcholine concentration accordingly decreased (60.5%) in the 227.6 µg/L exposure group. The mRNA expressions of genes encoding myelin basic protein, neuron microtubule protein (α1-tubulin), and sonic hedgehog a were significantly downregulated. Western blotting assay demonstrated that the protein concentration of α1-tubulin was also decreased. Overall, this study demonstrated that acute exposure to PBDEs can disrupt the neurobehavior of zebrafish larvae and affect cholinergic neurotransmission and neuron development. Environ. Toxicol. Chem. © 2012 SETAC. |
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Authors:
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Lianguo Chen; Changjiang Huang; Chenyan Hu; Ke Yu; Lihua Yang; Bingsheng Zhou |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-25 |
Journal Detail:
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Title: Environmental toxicology and chemistry / SETAC Volume: - ISSN: 1552-8618 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308958 Medline TA: Environ Toxicol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 SETAC. |
Affiliation:
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State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; Graduate School of the Chinese Academy of Sciences, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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