Document Detail

Acute exercise reduces the effects of a 35% CO2 challenge in patients with panic disorder.
MedLine Citation:
PMID:  17727960     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic exercise has been shown to have therapeutic effects in panic disorder (PD). The mechanism of these effects is unknown. Acute exercise reduces the effect of a panic challenge in healthy volunteers. Such an effect has not yet been demonstrated in PD patients. The present study aimed at exploring the antipanic effects of acute exercise on a 35% CO2 panic provocation in treatment-naïve PD patients to further elucidate the mechanisms of the beneficial effects of exercise on panic. METHODS: Eighteen PD patients performed either moderate/hard exercise or very-light exercise before a 35% CO2 challenge in a randomized, between-group design. The reactivity to CO2 was assessed with the Visual Analogue Anxiety Scale and the DSM-IV Panic Symptom List. RESULTS: Panic reactions to CO2 were smaller in patients that performed moderate/hard exercise in contrast to those that performed very-light exercise. Increments in both measurements and panic rates were consistently reduced by intense exercise. LIMITATIONS: Since this study focuses on the acute effects of exercise on CO2 sensitivity in patients with PD, the results of repetitive exercise sessions on the rate of spontaneous panic attacks and overall symptoms are warranted. The small sample size and other limitations are addressed. CONCLUSIONS: Exercise reduced the panicogenic effects of a CO2 challenge. In addition to its therapeutic potential, exercise may also be useful as a laboratory maneuver with heuristic value in experimental research into the mechanisms of antipanic treatment.
Gabriel Esquivel; John Díaz-Galvis; Koen Schruers; Carlos Berlanga; Carmen Lara-Muñoz; Eric Griez
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2007-08-28
Journal Detail:
Title:  Journal of affective disorders     Volume:  107     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-05-27     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
Academic Anxiety Center, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.
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MeSH Terms
Carbon Dioxide / administration & dosage*,  diagnostic use
Diagnostic and Statistical Manual of Mental Disorders
Exercise / physiology*
Exercise Therapy / methods
Lactates / blood
Panic Disorder / blood,  chemically induced*,  prevention & control*
Physical Exertion / physiology
Psychiatric Status Rating Scales
Treatment Outcome
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide

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