Document Detail

Acute exercise protects against doxorubicin cardiotoxicity.
MedLine Citation:
PMID:  18815146     Owner:  NLM     Status:  MEDLINE    
Numerous methods have been used to minimize the cardiotoxic effects of the chemotherapeutic agent doxorubicin (DOX), and most have had limited success. Chronic endurance exercise has been shown to protect against DOX cardiotoxicity, but little is known regarding the effects of acute exercise on DOX-induced cardiac dysfunction. PURPOSE: The purpose of this study was to determine the effects of a single bout of acute endurance exercise on the cardiac dysfunction associated with DOX treatment. METHODS: Male Sprague-Dawley rats either performed an acute exercise bout on a motorized treadmill for 60 minutes at a maximal speed of 25 m/min with a 5% grade (EX) or remained sedentary (SED) 24 hours before receiving either a 15-mg/kg DOX bolus dose or saline (SAL). Cardiac function was then analyzed 5 days post injection using a Langendorff isolated perfused heart model. In addition, myocardial lipid peroxidation was analyzed as an indicator of oxidative stress. RESULTS: Doxorubicin treatment alone (SED+DOX) promoted a significant decline in end-systolic pressure (-35%), left ventricular developed pressure (-59%), and the maximal rate of left ventricular pressure development (-43%) as well as a 45% increase in lipid peroxidation products when compared with SED+SAL (P<.05). Acute exercise 24 hours before DOX treatment, however, had a cardioprotective effect, as end-systolic pressure, left ventricular developed pressure, and the maximal rate of left ventricular pressure development were significantly higher in EX+DOX compared with SED+DOX (P<.05) and EX+DOX had similar levels of lipid peroxidation products as SED+SAL CONCLUSIONS: An acute exercise bout performed 24 hours before DOX treatment protected against cardiac dysfunction, and this exercise-induced cardioprotection may partly be explained by a reduction in the generation of reactive oxygen species.
Karen Y Wonders; David S Hydock; Carole M Schneider; Reid Hayward
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Integrative cancer therapies     Volume:  7     ISSN:  1534-7354     ISO Abbreviation:  Integr Cancer Ther     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-25     Completed Date:  2009-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128834     Medline TA:  Integr Cancer Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Department of Health, Physical Education, and Recreation, Wright State University, Dayton, Ohio, USA.
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MeSH Terms
Antibiotics, Antineoplastic / toxicity*
Blood Pressure / drug effects
Disease Models, Animal
Doxorubicin / toxicity*
Heart Diseases / chemically induced,  prevention & control*
Lipid Peroxidation / drug effects
Oxidative Stress / drug effects
Physical Conditioning, Animal*
Rats, Sprague-Dawley
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Reactive Oxygen Species; 23214-92-8/Doxorubicin

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