Document Detail

Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats.
MedLine Citation:
PMID:  19273580     Owner:  NLM     Status:  MEDLINE    
PGC-1alpha expression is a tissue-specific regulatory feature that is extremely relevant to diabetes. Several studies have shown that PGC-1alpha activity is atypically activated in the liver of diabetic rodents and contributes to hepatic glucose production. PGC-1alpha and Foxo1 can physically interact with one another and represent an important signal transduction pathway that governs the synthesis of glucose in the liver. However, the effect of physical activity on PGC-1alpha/Foxo1 association is unknown. Here we investigate the expression of PGC-1alpha and the association of PGC-1alpha/Foxo1 in the liver of diet-induced obese rats after acute exercise. Wistar rats swam for two 3 h-long bouts, separated by a 45 min rest period. Eight hours after the acute exercise protocol, the rats were submitted to an insulin tolerance test (ITT) and biochemical and molecular analysis. Results demonstrate that acute exercise improved insulin signalling, increasing insulin-stimulated Akt and Foxo1 phosphorylation and decreasing PGC-1alpha expression and PGC-1alpha/Foxo1 interaction in the liver of diet-induced obesity rats under fasting conditions. These phenomena are accompanied by a reduction in the expression of gluconeogenesis genes, such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphate (G6Pase). Thus, these results provide new insights into the mechanism by which exercise could improve fasting hyperglycaemia.
Eduardo R Ropelle; José R Pauli; Dennys E Cintra; Marisa J S Frederico; Ricardo A de Pinho; Lício A Velloso; Cláudio T De Souza
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-09
Journal Detail:
Title:  The Journal of physiology     Volume:  587     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-07-09     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2069-76     Citation Subset:  IM    
Departamento de Clínica Médica, FCM, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
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MeSH Terms
Dietary Fats / adverse effects*
Forkhead Transcription Factors / metabolism*
Liver / physiopathology*
Nerve Tissue Proteins / metabolism*
Obesity / etiology,  physiopathology*
Physical Endurance*
RNA-Binding Proteins / metabolism*
Rats, Wistar
Signal Transduction*
Transcription Factors / metabolism*
Reg. No./Substance:
0/Dietary Fats; 0/Forkhead Transcription Factors; 0/Nerve Tissue Proteins; 0/Ppargc1a protein, rat; 0/RNA-Binding Proteins; 0/Transcription Factors; 147604-79-3/Foxo1 protein, rat

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