Document Detail

Acute-exercise-induced alterations in calpain and calpastatin expression in rat muscle.
MedLine Citation:
PMID:  19561365     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Calpains and calpastatin can degrade muscle proteins, but no research has investigated the expression pattern of calpains and calpastatin after exhaustive exercise. OBJECTIVE: To investigate the alterations in expression of micro-, m-, and n-calpain and calpastatin after exhaustive exercise and its association with muscle injury. METHOD: 64 rats divided into 2 groups, a nonexercise control group and an acute-exhaustive-exercise (AEE) group. Biopsies in the AEE group were taken at different times after exercise. RESULTS: Calpastatin protein expression and m-calpain activity increased early after exercise, but both n-calpain protein expression and micro-calpain activity generally decreased with time. n-Calpain mRNA expression was down-regulated from late after exercise. CONCLUSIONS: The increased m-calpain activity might promote muscle-protein degradation and muscle injury. On the contrary, calpastatin might execute a protective function against muscle injury. The change in micro-calpain activity was found earlier than muscle injury and therefore might serve as a useful predictor of muscle injury.
Lijing Wang; Ligong Duan; Xukan Li; Guoping Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of sport rehabilitation     Volume:  18     ISSN:  1056-6716     ISO Abbreviation:  J Sport Rehabil     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206500     Medline TA:  J Sport Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-28     Citation Subset:  IM    
First Clinical Medical College, Nanjing Medical University, and the Department of Physical Education, Southeast University, Nanjing, 210029, China.
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MeSH Terms
Calcium-Binding Proteins / genetics,  metabolism*
Calpain / genetics,  metabolism*
Muscle, Skeletal / metabolism*
Physical Conditioning, Animal*
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/RNA, Messenger; 79079-11-1/calpastatin; EC 3.4.22.-/Calpain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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