| Acute-exercise-induced alterations in calpain and calpastatin expression in rat muscle. | |
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MedLine Citation:
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PMID: 19561365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Calpains and calpastatin can degrade muscle proteins, but no research has investigated the expression pattern of calpains and calpastatin after exhaustive exercise. OBJECTIVE: To investigate the alterations in expression of micro-, m-, and n-calpain and calpastatin after exhaustive exercise and its association with muscle injury. METHOD: 64 rats divided into 2 groups, a nonexercise control group and an acute-exhaustive-exercise (AEE) group. Biopsies in the AEE group were taken at different times after exercise. RESULTS: Calpastatin protein expression and m-calpain activity increased early after exercise, but both n-calpain protein expression and micro-calpain activity generally decreased with time. n-Calpain mRNA expression was down-regulated from late after exercise. CONCLUSIONS: The increased m-calpain activity might promote muscle-protein degradation and muscle injury. On the contrary, calpastatin might execute a protective function against muscle injury. The change in micro-calpain activity was found earlier than muscle injury and therefore might serve as a useful predictor of muscle injury. |
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Authors:
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Lijing Wang; Ligong Duan; Xukan Li; Guoping Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of sport rehabilitation Volume: 18 ISSN: 1056-6716 ISO Abbreviation: J Sport Rehabil Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206500 Medline TA: J Sport Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 213-28 Citation Subset: IM |
Affiliation:
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First Clinical Medical College, Nanjing Medical University, and the Department of Physical Education, Southeast University, Nanjing, 210029, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biopsy Calcium-Binding Proteins / genetics, metabolism* Calpain / genetics, metabolism* Male Muscle, Skeletal / metabolism* Physical Conditioning, Animal* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Proteins; 0/RNA, Messenger; 79079-11-1/calpastatin; EC 3.4.22.-/Calpain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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