| Acute exercise increases the number of plasma membrane glucose transporters in rat skeletal muscle. | |
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MedLine Citation:
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PMID: 2844599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether increased glucose transport following exercise is associated with an increased number of glucose transporters in muscle plasma membranes, the D-glucose inhibitable cytochalasin B binding technique was used to measure glucose transporters in red gastrocnemius muscle from exercised (1 h treadmill) or sedentary rats. Immediately following exercise there was a 2-fold increase in cytochalasin B binding sites, measured in purified plasma membranes enriched 30-fold in 5'-nucleotidase activity. This increase in glucose transporters in the plasma membrane may explain in part, the increase in glucose transport rate which persists in skeletal muscle following exercise. Where these transporters originate, remains to be elucidated. |
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Authors:
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M F Hirshman; H Wallberg-Henriksson; L J Wardzala; E D Horton; E S Horton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: FEBS letters Volume: 238 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-11-14 Completed Date: 1988-11-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 235-9 Citation Subset: IM; S |
Affiliation:
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Department of Medicine, University of Vermont, College of Medicine, Burlington 05405. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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5'-Nucleotidase Animals Body Weight Cell Membrane / metabolism Cytochalasin B / metabolism Male Monosaccharide Transport Proteins / metabolism* Muscle Proteins / metabolism Muscles / anatomy & histology, metabolism* Nucleotidases / metabolism Organ Size Physical Exertion* Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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R01 AM26317-06/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Monosaccharide Transport Proteins; 0/Muscle Proteins; 14930-96-2/Cytochalasin B; EC 3.1.3.-/Nucleotidases; EC 3.1.3.5/5'-Nucleotidase |
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