Document Detail

Acute exercise enhancement of pneumococcal vaccination response: a randomised controlled trial of weaker and stronger immune response.
MedLine Citation:
PMID:  22921739     Owner:  NLM     Status:  MEDLINE    
Acute exercise at the time of vaccination can enhance subsequent immune responses. However, the potential benefit of this effect will be its efficacy in boosting poor responses, and thus protection in at-risk populations. The current study tested the effect of exercise on the response to either a full- or half-dose Pneumococcal (Pn) vaccination to elicit stronger and weaker responses. Subjects were 133 young healthy adults, randomised to one of four groups: exercise or control task, receiving a full- or half-dose Pn vaccination. Prior to vaccination, exercise groups completed a 15 min arm and shoulder exercise task, control groups rested quietly. Antibody levels to 11 Pn strains were evaluated at baseline and 1-month. Across all participants, exercise groups showed significantly greater increase in antibody levels than control groups. When doses were compared, it emerged that those who exercised had significantly larger responses than those who rested in the half-dose group, but in the full-dose groups responses were similar. This data indicates the effectiveness of exercise as a vaccine adjuvant, particularly in weaker responses. Thus, given the potential public health benefits of no-cost behavioural intervention to enhance response to vaccination, testing in at-risk populations should be pursued.
Kate M Edwards; Meredith A Pung; Lianne M Tomfohr; Michael G Ziegler; John P Campbell; Mark T Drayson; Paul J Mills
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-22
Journal Detail:
Title:  Vaccine     Volume:  30     ISSN:  1873-2518     ISO Abbreviation:  Vaccine     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  2013-02-11     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  6389-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
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MeSH Terms
Antibodies, Bacterial / blood
Antibody Formation*
Dose-Response Relationship, Immunologic*
Granulocyte-Macrophage Colony-Stimulating Factor / blood
Interleukin-6 / blood
Pneumococcal Infections / immunology,  prevention & control
Pneumococcal Vaccines / administration & dosage,  immunology*
Young Adult
Grant Support
Reg. No./Substance:
0/Antibodies, Bacterial; 0/IL6 protein, human; 0/Interleukin-6; 0/Pneumococcal Vaccines; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

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