Document Detail


Acute exercise does not attenuate postprandial oxidative stress in prediabetic women.
MedLine Citation:
PMID:  20048485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individuals with impaired lipid and glucose metabolism are at increased risk for postprandial oxidative stress. Acute exercise can attenuate the rise in both blood triglyceride (TAG) and glucose, and increase antioxidant enzyme activity after food intake, which may decrease the oxidative stress response. This study investigated the effect of acute exercise on blood TAG and oxidative stress biomarkers in prediabetic women. Sixteen prediabetic women (30 +/- 3 years of age; fasting blood glucose, 107 +/- 3 mg x dL(-1); body mass index, 32 +/- 2 kg x m(-2)) consumed a high-fat meal with and without a session of aerobic exercise 15 minutes preceding the meal (45-minute duration, 65% heart rate reserve), in a random order cross-over design. Blood samples were collected premeal (fasted) and at 1, 2, 4, and 6 hours postmeal and assayed for Trolox equivalent antioxidant capacity (TEAC), xanthine oxidase (XO) activity, hydrogen peroxide (H2O2), malondialdehyde (MDA), TAG, and glucose. No interaction or condition main effects were noted (P > 0.05). However, time main effects were noted for XO, H2O2, MDA, and TAG (P < 0.0001), with values higher from 1 to 6 hours postmeal compared with premeal, and for TEAC (P = 0.05), with values lower at 4 hours postmeal. Glucose remained relatively unchanged (P > 0.05). Acute exercise, performed at the intensity and duration of the present study, does not influence postprandial TAG and oxidative stress in obese prediabetic women. Such individuals may need a greater volume of exercise for measurable effects.
Authors:
Courtnee E Melton; Patrick S Tucker; Kelsey H Fisher-Wellman; Brian K Schilling; Richard J Bloomer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Physician and sportsmedicine     Volume:  37     ISSN:  0091-3847     ISO Abbreviation:  Phys Sportsmed     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0427461     Medline TA:  Phys Sportsmed     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-36     Citation Subset:  IM    
Affiliation:
Cardiorespiratory/Metabolic Laboratory, The University of Memphis, Memphis, TN 38152, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Anthropometry
Antioxidants / metabolism
Biological Markers / blood*
Blood Glucose / analysis
Cross-Over Studies
Dietary Fats / administration & dosage
Exercise / physiology*
Exercise Test
Female
Humans
Hydrogen Peroxide / blood
Malondialdehyde / blood
Obesity / blood*
Oxidative Stress / physiology*
Postprandial Period / physiology*
Prediabetic State*
Questionnaires
Triglycerides / blood
Xanthine Oxidase / blood
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Blood Glucose; 0/Dietary Fats; 0/Triglycerides; 542-78-9/Malondialdehyde; 7722-84-1/Hydrogen Peroxide; EC 1.17.3.2/Xanthine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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