| Acute evaluation of pituitary function in patients with crimean congo haemorrhagic fever. | |
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MedLine Citation:
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PMID: 21767285 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context: Crimean Congo Haemorrhagic Fever (CCHF) can cause a fatal haemorrhagic syndrome. Pituitary ischaemia/infarction and necrosis are known causes of hypopituitarism, often remaining unrecognized due to subtle clinical manifestations. Objective: Our aim was to evaluate the effect of CCHF on pituitary function. Subject and methods: Levels of serum free T3, free T4, TSH, GH, IGF-I, prolactin, cortisol, testosterone (in males) and oestrogen (in females) were studied in 20 patients who had been diagnosed as CCHF. TRH, LH-RH and 1μg adrenocorticotropin tests were performed in all patients. The hypothalamo-pituitary region was examined by magnetic resonance imaging in two patients who were diagnosed as hypocortisolism. Results: We found cortisol insufficiency in two (10%) of the twenty with CCHF. However, hypophyseal magnetic resonance imaging findings were normal in these two patients. None of the patients had deficiencies of GH, TSH, or FSH/LH. Conclusion: To our knowledge, this is the first study reporting the effect of CCHF on pituitary function. We found that cortisol insufficiency may occur in patients diagnosed with CCHF; however, studies including a larger number of patients are required to make a definite conclusion on this issue. |
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Authors:
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Fatih Kiliçli; Hatice Sebila Dökmetaş; Ilyas Dökmetaş |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-18 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Cumhuriyet University, Faculty of Medicine, Department of Endocrinology and Metabolism, Sivas, TURKEYCumhuriyet University, Faculty of Medicine, Department of Endocrinology and Metabolism, Sivas, TURKEYCumhuriyet University, Faculty of Medicine, Department of Infectious Disease and Clinical Microbiology, Sivas, TURKEY. |
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