Document Detail


Acute ethanol administration reduces the cognitive deficits associated with traumatic brain injury in rats.
MedLine Citation:
PMID:  9512086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was designed to determine whether a low dose of acute ethanol administration could attenuate cognitive deficits associated with traumatic brain injury. Adult male rats received oral administration of ethanol or drinking water 2 h prior to surgery to produce a blood ethanol concentration of 100 mg% and then received bilateral contusion injuries of the medial prefrontal cortex. Seven days after surgery, the rats began 10 days of testing for acquisition of spatial localization in the Morris water maze where they were required to find a hidden platform to escape from the water. The results indicate that the rats given ethanol at the time of injury later spent significantly less time searching for the hidden platform than their water-treated counterparts. On a memory probe test given on the final day of testing, in which the platform was removed from the pool, rats given the ethanol spent more time in the area where the platform had been located indicating that they learned its location better than the lesion/water controls. In addition, acute ethanol treatment reduced some of the histopathology that typically occurs following severe contusion of the medial frontal cortex but did not attenuate post-traumatic formation of edema. These results indicate that acute ethanol intoxication can reduce the severity of cognitive impairments caused by contusive traumatic brain injury and support the contention that there is a dose-response relationship of acute ethanol intoxication in the setting of traumatic brain injury.
Authors:
L S Janis; M R Hoane; D Conde; Z Fulop; D G Stein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurotrauma     Volume:  15     ISSN:  0897-7151     ISO Abbreviation:  J. Neurotrauma     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-08     Completed Date:  1998-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-15     Citation Subset:  IM    
Affiliation:
Institute of Animal Behavior, Rutgers University, Newark, NJ 07102, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology
Brain Concussion / complications,  pathology,  psychology
Brain Edema / etiology
Brain Injuries / complications*,  pathology,  psychology
Cognition Disorders / drug therapy*,  etiology*,  psychology
Ethanol / therapeutic use*
Male
Maze Learning / drug effects
Mortality
Rats
Rats, Sprague-Dawley
Swimming
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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