Document Detail

Acute estrogen administration can reverse cold-induced coronary Raynaud's phenomenon in systemic sclerosis.
MedLine Citation:
PMID:  8871843     Owner:  NLM     Status:  MEDLINE    
A 52-year-old postmenopausal woman with long-standing progressive systemic sclerosis and Raynaud's phenomenon was examined by dipyridamole-thallium-201 myocardial imaging and cold pressor thallium-201 myocardial scintigraphy. The dipyridamole test revealed normal myocardial perfusion, while the cold pressor test showed reversible ischemia to the anteroapical myocardial wall, indicating coronary Raynaud's phenomenon. Acute intravenous administration of conjugated estrogens led to normalization of the cold-induced thallium-201 defect. This is the first reported case of the beneficial effect of estrogens in coronary Raynaud's phenomenon.
J Lekakis; M Mavrikakis; M Emmanuel; V Prassopoulos; C Papamichael; D Moulopoulou; A Ziaga; P Kostamis; S Moulopoulos
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  14     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  421-4     Citation Subset:  IM    
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece.
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MeSH Terms
Cold Temperature / adverse effects*
Coronary Disease / drug therapy*,  etiology,  radionuclide imaging
Dipyridamole / administration & dosage
Estrogens / administration & dosage*
Heart / radionuclide imaging
Injections, Intravenous
Middle Aged
Raynaud Disease / drug therapy*,  etiology,  radionuclide imaging
Scleroderma, Systemic / complications*,  drug therapy,  radionuclide imaging
Thallium Radioisotopes / diagnostic use
Vasodilator Agents / administration & dosage
Reg. No./Substance:
0/Estrogens; 0/Thallium Radioisotopes; 0/Vasodilator Agents; 58-32-2/Dipyridamole

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