| Acute erythroid leukemia as defined in the World Health Organization classification is a rare and pathogenetically heterogeneous disease. | |
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MedLine Citation:
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PMID: 20473273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The diagnostic criteria for acute erythroid leukemia have been controversial since this disease was initially described. Using the current World Health Organization classification criteria, we retrospectively reviewed cases of acute myeloid leukemia or myelodysplastic syndrome in which erythroid precursors were >or=50% of the bone marrow nucleated cell population and the diagnosis of erythroleukemia was considered using older classification schemes. We collected 90 cases and separated them into four diagnostic groups: acute erythroid leukemia, erythroleukemia or erythroid/myeloid type (n=20); acute myeloid leukemia with myelodysplasia-related changes (n=22); therapy-related acute myeloid leukemia (n=32); and refractory anemia with excess blasts and preceding or concurrent history of erythropoietin therapy for anemia (n=16). Patients with acute erythroid leukemia were the youngest patient group and had the best overall survival. There was a statistically significant difference in overall survival between patients with acute erythroid leukemia versus acute myeloid leukemia with myelodysplasia-related changes (P=0.003) and between patients with acute erythroid leukemia versus therapy-related acute myeloid leukemia (P<0.0001). The presence of complex cytogenetic abnormalities (>3) was the only statistically significant independent variable that adversely affected survival in the acute erythroid leukemia group. Monosomy 5/del(5q) and monosomy 7/del(7q) were overrepresented in the context of complex chromosomal abnormalities. Our data suggest that acute erythroid leukemia, as currently defined in the World Health Organization classification, has become a rare disease. A majority of the cases reported previously as erythroleukemia are now classified as other entities. In addition, our data suggest that the current definition of acute erythroid leukemia, erythroleukemia type remains heterogeneous. One subset of acute erythroid leukemia patients has relatively low blast counts and are diploid. The prognosis of this patient subset is relatively good. The other subset has cytogenetic abnormalities similar to those in myelodysplastic syndromes and a poor prognosis. |
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Authors:
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Armen Kasyan; L Jeffrey Medeiros; Zhuang Zuo; Favio P Santos; Farhad Ravandi-Kashani; Roberto Miranda; Saroj Vadhan-Raj; Hartmut Koeppen; Carlos E Bueso-Ramos |
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Publication Detail:
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Type: Journal Article Date: 2010-05-14 |
Journal Detail:
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Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Volume: 23 ISSN: 1530-0285 ISO Abbreviation: Mod. Pathol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806605 Medline TA: Mod Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 1113-26 Citation Subset: IM |
Affiliation:
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Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anemia, Refractory / pathology Bone Marrow Cells / pathology Bone Marrow Transplantation Child Chromosome Aberrations Erythroblasts / pathology Erythroid Cells / pathology* Female Humans Leukemia, Erythroblastic, Acute / genetics, mortality, pathology* Male Middle Aged Myelodysplastic Syndromes / genetics, mortality, pathology* Prognosis Retrospective Studies Survival Rate Texas / epidemiology World Health Organization Young Adult |
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