| Acute encephalopathy with biphasic seizures and late reduced diffusion associated with hemophagocytic syndrome. | |
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MedLine Citation:
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PMID: 19556082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reported a girl with HHV-6 infection associated with both acute encephalopathy with biphasic seizures and late reduced diffusion, and hemophagocytic syndrome. She had a prolonged convulsion after a one-day history of febrile illness. Cerebrospinal fluid or brain CT showed no abnormalities on admission and her consciousness was recovered on the next day. However, a prolonged seizure and deterioration of consciousness appeared on the sixth day of illness. Diffusion-weighted images revealed marked reduction of water diffusion in the bilateral frontal areas. HHV-6 infection was virologically proven by polymerase chain reaction. She was treated with gamma-globulin, steroid pulse therapy, and brain hypothermia. In addition, decrease in white blood cells and platelet counts, and elevation of liver enzymes and ferritin were noted on the fourth day of illness. Hemophagocytic macrophages were revealed by bone marrow aspiration on the sixth day. Her hematological and blood chemistry abnormalities recovered gradually after steroid pulse therapy. An elevation of interleukin-6, -8, and -10, and tumor necrosis factor in the serum and that of interleukin-4, -6, and-8 in the cerebrospinal fluid were observed at the onset of a late seizure. These facts suggested that hypercytokinemia will be related to the pathogenesis of acute encephalopathy of our patient. |
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Authors:
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Rieko Tadokoro; Akihisa Okumura; Tomoyuki Nakazawa; Satoshi Hara; Yoko Yamakawa; Ayako Kamata; Keiji Kinoshita; Kaoru Obinata; Toshiaki Shimizu |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-24 |
Journal Detail:
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Title: Brain & development Volume: 32 ISSN: 1872-7131 ISO Abbreviation: Brain Dev. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 477-81 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatrics, Koshigaya Municipal Hospital, Saitama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Bone Marrow / pathology, physiopathology Brain / pathology, physiopathology, radiography Brain Diseases / pathology, physiopathology*, therapy Diffusion Magnetic Resonance Imaging Disease Progression Female Herpesvirus 6, Human* Humans Infant Lymphohistiocytosis, Hemophagocytic / pathology, physiopathology*, therapy Roseolovirus Infections / pathology, physiopathology*, therapy Seizures / pathology, physiopathology*, therapy Time Factors Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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