| Acute elevation of lipids does not alter exercise hemodynamics in healthy men: A randomized controlled study. | |
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MedLine Citation:
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PMID: 23137823 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Exaggerated exercise blood pressure (BP) predicts mortality. Some studies suggest this could be explained by chronic hyperlipidemia, but whether acute-hyperlipidemia effects exercise BP has never been tested, and was the aim of this study. METHODS: Intravenous infusion of saline (control) and Intralipid were administered over 60 min in 15 healthy men by double-blind, randomized, cross-over design. Brachial and central BP (including, pulse pressure, augmentation pressure and augmentation index), cardiac output and systemic vascular resistance were recorded at rest and during exercise. RESULTS: Compared with control, Intralipid caused significant increases in serum triglycerides, very low density lipoproteins and free fatty acids (p < 0.001 for all). However, there was no significant difference for any exercise hemodynamic variable (p > 0.05 for all). CONCLUSION: Acute-hyperlipidemia does not significantly change exercise hemodynamics in healthy males. Therefore, the association between raised lipids and increased exercise BP is likely due to the chronic effects of hyperlipidemia. |
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Authors:
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James E Sharman; David J Holland; Rodel Leano; Karam M Kostner |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-26 |
Journal Detail:
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Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2012. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia; University of Queensland, Department of Medicine, Brisbane, Australia. Electronic address: James.Sharman@menzies.utas.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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