Document Detail


Acute effects of tea on fasting and postprandial vascular function and blood pressure in humans.
MedLine Citation:
PMID:  15643124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Effects of regular exposure to polyphenolic compounds found in tea, leading to improved endothelial function and blood pressure, may reduce cardiovascular disease risk. Controlled trials in humans have found that ingestion of tea can improve endothelial function, but also cause a rapid onset acute increase in blood pressure. OBJECTIVE: To examine the acute effects of tea consumption on fasting and postprandial vascular function and blood pressure. METHODS: Endothelium-dependent dilatation of the brachial artery, assessed using ultrasound and blood pressure were measured in 20 participants with a history of coronary artery disease. Measurements were performed at baseline and at 3.5 h (blood pressure) and 4 h (endothelial function) after drinking three cups of black tea or hot water (consumed at time = 0, 1.5 and 3 h) with and without a high-fat (50 g) meal: a total of four treatments administered in random order. RESULTS: The high-fat meal did not impair endothelial function. In comparison to water alone, endothelium-dependent dilatation was increased by the meal with tea (1.7 (0.4, 3.0)%, P = 0.02), but was not significantly altered by the tea alone (0.7 (-0.6, 2.0)%, P = 0.32). Systolic blood pressure was significantly increased by tea alone in comparison to each of the other three groups: water alone (9.3 (4.5, 14.1) mmHg, P = 0.0003), meal with water (9.8 (5.0, 14.6) mmHg, P = 0.0001) and meal with tea (7.2 (2.4,12.0) mmHg, P = 0.004). Consumption of a meal negated the acute increase in systolic blood pressure found with tea in the fasting state. CONCLUSION: Consumption of food may alter the acute effects of tea on vascular function and blood pressure.
Authors:
Jonathan M Hodgson; Valerie Burke; Ian B Puddey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  23     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-11     Completed Date:  2005-05-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Affiliation:
University of Western Australia School of Medicine and Pharmacology, Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital Unit, Perth, Western Australia. jonathan@cyllene.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure / drug effects*
Brachial Artery / physiology
Caffeine / administration & dosage,  blood
Central Nervous System Stimulants / administration & dosage,  blood
Dietary Fats / administration & dosage
Endothelium, Vascular / drug effects*,  physiology
Fasting
Female
Flavonoids / administration & dosage,  blood
Humans
Hypertension / drug therapy*,  physiopathology
Middle Aged
Phenols / administration & dosage,  blood
Postprandial Period
Tea*
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Dietary Fats; 0/Flavonoids; 0/Phenols; 0/Tea; 0/polyphenols; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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